AI Article Synopsis
- The study aimed to evaluate the indocyanine green retention rate at 15 minutes (ICG-R15) as a prognostic marker for patients with hepatocellular carcinoma (HCC) undergoing transcatheter arterial chemoembolization (TACE) therapy.
- Researchers analyzed data from 278 HCC patients using statistical models to determine the association between ICG-R15 and overall survival.
- Findings indicated that patients with an ICG-R15 greater than 20% had significantly better survival outcomes compared to those with an ICG-R15 below 20%, establishing higher ICG-R15 as a positive prognostic factor in this context.
Article Abstract
Purpose: To test indocyanine green retention rate at 15 minutes (ICG-R15) as a prognostic biomarker in patients with hepatocellular carcinoma (HCC) treated with transcatheter arterial chemoembolization (TACE) therapy.
Materials And Methods: This retrospective cohort study was performed on the data of 278 consecutive patients with HCC treated with TACE after ICG-R15 testing at a single university hospital. Cox proportional hazard model analysis was performed to identify independent prognostic factors. After adjusting for age, sex, stage of HCC, albumin-bilirubin score, etiologies, and baseline year by propensity score matching, the prognostic impact of higher ICG-R15 was evaluated using the Kaplan-Meier curve.
Results: Univariate and multivariate analyses identified higher ICG-R15 as a positive prognostic factor for overall survival. Propensity score matching generated two 77-patient cohorts: ICG-R15 <20% group and ICG-R15 >20% group. The overall survival of the ICG-R15 >20% group was significantly better than that of the ICG-R15 <20% group.
Conclusions: Higher ICG-R15 acted as a positive long-term prognostic factor in patients with HCC treated with TACE.
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| http://dx.doi.org/10.1016/j.jvir.2023.11.005 | DOI Listing |
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