[This corrects the article DOI: 10.1371/journal.pone.0264958.].
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0294704 | PLOS |
J Crohns Colitis
January 2025
Amsterdam UMC, Department of Gastroenterology and Hepatology, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
Introduction: It remains unclear why up to 30% of ulcerative colitis patients (UC) do not respond to tumor necrosis factor inhibitors (TNFi). Validated biomarkers for (non-)response ((N)R) are lacking. Most studies investigating underlying mechanisms do not differentiate between pharmacokinetic and inflammatory mechanisms.
View Article and Find Full Text PDFClin Chem Lab Med
January 2025
70777 TUBITAK National Metrology Institute (TUBITAK UME), Kocaeli, Türkiye.
Objectives: An analytical protocol based on isotope dilution liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS), which includes a peptide-based calibration strategy, was developed and validated for the determination of cardiac troponin I (cTnI) levels in clinical samples. Additionally, the developed method was compared with a protein-based calibration strategy, using cTnI serving as a model for low-abundant proteins. The aim is to evaluate new approaches for protein quantification in complex matrices, supporting the metrology community in implementing new methods and developing fit-for-purpose SI- traceable peptide or protein primary calibrators.
View Article and Find Full Text PDFSci Rep
December 2024
College of Electrical and Information Engineering, Quzhou University, Quzhou, 324000, China.
A new kernel function, termed the closed-box kernel function, has been developed to address numerical simulation of transient heat conduction in the same medium. Firstly, this method is versatile and not limited to specific industrial scenarios or designated materials. Secondly, the method solves the spatial temperature at each time point only once, eliminating the need for multiple iterations.
View Article and Find Full Text PDFJ Funct Morphol Kinesiol
December 2024
Department of Sports Management and Physical Activity, Catholic University of Valencia, 46900 Valencia, Spain.
The proper development of balance is essential in the acquisition of a correct physical condition, as well as in the evolutionary follow-up at early ages, and its periodic evaluation is very relevant in the educational environment. : The objective of this research was to design an accessible web application for static and dynamic balance assessment, based on a force platform and motion analysis software. : The Single leg balance test (SLB), Tandem balance test (TBT), and Y balance test (YBT) were performed on a sample of 75 children aged 6 to 9 years.
View Article and Find Full Text PDFWorld J Clin Cases
December 2024
Department of Ophthalmology, Tung Wah Eastern Hospital, Hong Kong 999077, China.
Upper lid blepharoplasty is a surgical procedure that requires meticulous planning and execution. It is not a standalone procedure but can be combined with ptosis correction surgery. Prior to surgery, thorough lid examinations are essential to determine the appropriate approaches.
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