Purpose: To evaluate changes in intraocular pressure (IOP) at different gaze positions before and after superior rectus muscle-lateral rectus muscle (SR-LR) loop myopexy in highly myopic strabismus (HMS).
Study Design: Nonrandomized clinical, prospective, interventional trial.
Methods: Fourteen patients with HMS (18 eyes) who underwent SR-LR loop myopexy were divided into 3 groups: < 100 prism diopters (PD) (mild esotropia [ET] group), > 100 PD (large ET group), and > 100 PD, and simultaneous recession of the medial rectus (MR) muscle was performed (large ET + MR group). Intraocular pressure was measured preoperatively and postoperatively at the primary, abduction, and adduction positions in each group.
Results: Intraocular pressure did not change after surgery in the mild ET group. Intraocular pressure significantly decreased in the abduction position (from 20.0 ± 2.1 to 16.0 ± 1.9 mmHg, P = 0.043) in the large ET group and in the abduction (from 22.2 ± 5.9 to 15.6 ± 4.3 mmHg, P = 0.048) and primary positions (from 15.8 ± 5.0 to 10.2 ± 2.8 mmHg, P = 0.043) in the large ET + MR group. The preoperative significant differences in IOP between the abduction and adduction positions in the large ET group (7.4 ± 3.4 mmHg) and the large ET + MR group (10.0 ± 5.5 mmHg) disappeared postoperatively (3.2 ± 2.8 mmHg and 3.6 ± 1.7 mmHg, respectively). The differences in IOP between abduction and adduction were similar in all the groups.
Conclusion: SR-LR loop myopexy decreased IOP in patients with HMS in the abduction and primary positions.
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http://dx.doi.org/10.1007/s10384-023-01032-4 | DOI Listing |
Am J Manag Care
January 2025
Schaeffer Center for Health Policy & Economics, University of Southern California, 635 Downey Way, Verna & Peter Dauterive Hall, Los Angeles, CA 90089. Email:
Objectives: To assess trends in the medical loss ratio (MLR) and understand how health insurance premiums in the large group market are driven by medical claims spending and insurer margins.
Study Design: Study of approximately 500 insurers covering more than 40 million lives annually in the large group market that submitted an MLR submission form (2014-2022).
Methods: We assessed trends in the MLR, premiums, medical claims spending, administrative costs, quality improvement spending, and margins among all insurers in the large group market.
PLoS One
January 2025
Department of Palaeontology, Faculty of Earth Sciences, Geography and Astronomy, Evolutionary Research Group, University of Vienna, Vienna, Austria.
The Late Jurassic fossil deposits of southern Germany, collectively known as the 'Solnhofen Archipelago', are one of the world's most important sources of Mesozoic vertebrates. Complete skeletons of cartilaginous fishes (Chondrichthyes), whose skeletal remains are rare in the fossil record and therefore all the more valuable, are represented, among others, by exceptionally well-preserved rays (superorder Batomorphii). Despite their potential for research in several areas, including taxonomy, morphology, ecology, and phylogeny, the number of studies on these chondrichthyans is still very limited.
View Article and Find Full Text PDFClin Trials
December 2024
Medical Research Council Clinical Trials Unit, University College London, London, UK.
Background: There is increasing recognition that the interpretation of active-controlled HIV prevention trials should consider the counterfactual placebo HIV incidence rate, that is, the rate that would have been observed if the trial had included a placebo control arm. The PrEPVacc HIV vaccine and pre-exposure prophylaxis trial (NCT04066881) incorporated a pre-trial registration cohort partly for this purpose. In this article, we describe our attempts to model the counterfactual placebo HIV incidence rate from the registration cohort.
View Article and Find Full Text PDFPLoS One
January 2025
Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust, Portsmouth, United Kingdom.
Background: Hospital Frailty Risk Score (HFRS) has recently been used to predict adverse health outcomes including length of stay (LOS) in hospital. LOS is an important indicator for patient quality of care, the measurement of hospital performance, efficiency and costs. Tools to predict LOS may enable earlier interventions in those identified at higher risk of a long stay.
View Article and Find Full Text PDFCell Rep
January 2025
Lendület Thalamus Research Group, HUN-REN Institute of Experimental Medicine, 1083 Budapest, Hungary. Electronic address:
Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Besides the inhibitory thalamic output, the BG directly control movement via specialized connections with the brainstem. Whether other parallel loops with similar logic exist is presently unclear.
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