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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM" IndexingMethod="Automated"><PMID Version="1">37966347</PMID><DateCompleted><Year>2023</Year><Month>12</Month><Day>16</Day></DateCompleted><DateRevised><Year>2023</Year><Month>12</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2165-0497</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>6</Issue><PubDate><Year>2023</Year><Month>Dec</Month><Day>12</Day></PubDate></JournalIssue><Title>Microbiology spectrum</Title><ISOAbbreviation>Microbiol Spectr</ISOAbbreviation></Journal><ArticleTitle>Classification of patients with COVID-19 by blood RNA endotype: a prospective cohort study.</ArticleTitle><Pagination><StartPage>e0264523</StartPage><MedlinePgn>e0264523</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">e02645-23</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1128/spectrum.02645-23</ELocationID><Abstract><AbstractText>In this study, whole-blood RNAs (prolactin and toll-like receptor 3) involved in the prognosis of patients with COVID-19 were identified. The RNA endotypes classified by these important RNAs highlight the possibility of stratifying the COVID-19 patient population and the need for targeted therapy based on these phenotypes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yoshimura</LastName><ForeName>Jumpei</ForeName><Initials>J</Initials><Identifier Source="ORCID">0000-0002-4092-8140</Identifier><AffiliationInfo><Affiliation>Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine , Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Togami</LastName><ForeName>Yuki</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine , Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ebihara</LastName><ForeName>Takeshi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine , Suita, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Infectious Disease Education and Research, Osaka University , Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matsumoto</LastName><ForeName>Hisatake</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0001-5771-570X</Identifier><AffiliationInfo><Affiliation>Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine , Suita, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Infectious Disease Education and Research, Osaka University , Suita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitsuyama</LastName><ForeName>Yumi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine , Suita, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Trauma and Surgical Critical Care, Osaka General Medical Center , Osaka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sugihara</LastName><ForeName>Fuminori</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Core Instrumentation Facility, Immunology Frontier Research Center and Research Institute for Microbial Diseases, Osaka University , Osaka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hirata</LastName><ForeName>Haruhiko</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine , Osaka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Okuzaki</LastName><ForeName>Daisuke</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Center for Infectious Disease Education and Research, Osaka University , Suita, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratory of Human Immunology (Single Cell Genomics), WPI Immunology Research Center, Osaka University , Osaka, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University , Osaka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ogura</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine , Suita, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Infectious Disease Education and Research, Osaka University , Suita, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>20fk0108404h0001</GrantID><Agency>Japan Agency for Medical Research and Development (AMED)</Agency><Country/></Grant><Grant><Agency>The Nippon Foundation Osaka University Project for Infectious Disease Prevention</Agency><Country/></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2023</Year><Month>11</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Microbiol Spectr</MedlineTA><NlmUniqueID>101634614</NlmUniqueID><ISSNLinking>2165-0497</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>63231-63-0</RegistryNumber><NameOfSubstance UI="D012313">RNA</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="Y">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012313" MajorTopicYN="N">RNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">clustering</Keyword><Keyword MajorTopicYN="N">phenotype</Keyword><Keyword MajorTopicYN="N">prognostic biomarker</Keyword><Keyword 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