AI Article Synopsis
- Emerging marine biotoxins like ciguatoxins and brevetoxins have been studied individually but their combined effects in seafood have not been thoroughly addressed in regulations.
- Research shows that these toxins exhibit a synergistic effect on human sodium channels, altering their activation and inactivation states.
- This study lays the groundwork for further investigation into other food toxins that may interact similarly, prompting the need for updated regulations to account for these combined risks to health.
Article Abstract
Emerging marine biotoxins such as ciguatoxins and brevetoxins have been widely and independently studied as food pollutants. Their maximum levels in food components were set without considering their possible synergistic effects as consequence of their coexistence in seafood and their action at the same cellular target. The absolute lack of data and regulations of the possible combined effects that both marine biotoxins may have raised the need to analyze their direct effects using electrophysiology techniques. The results presented in this study indicate that ciguatoxins and brevetoxins had a synergistic effect on human Na1.6 voltage-gated sodium channels by hyperpolarizing their activation and inactivation states. The results presented here indicate that brevetoxin 3 (BTX-3) acts as partial agonist of human sodium channels, while ciguatoxin 3C (CTX3C) was a full agonist, explaining the differences in the effect of each toxin in the channel. Therefore, this work sets the cellular basis to further apply this type of studies to other food toxicants that may act synergistically and thus implement the corresponding regulatory limits considering their coexistence and the risks to human and animal health derived from it.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10845145 | PMC |
| http://dx.doi.org/10.1021/acs.chemrestox.3c00267 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A multifunctional quasi-solid-state polymer electrolyte with highly selective ion highways for practical zinc ion batteries.
Nat Commun
January 2025
State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China.
The uncontrolled dendrite growth and detrimental parasitic reactions of Zn anodes currently impede the large-scale implementation of aqueous zinc ion batteries. Here, we design a versatile quasi-solid-state polymer electrolyte with highly selective ion transport channels via molecular crosslinking of sodium polyacrylate, lithium magnesium silicate and cellulose nanofiber. The abundant negatively charged ionic channels modulate Zn desolvation process and facilitate ion transport.
View Article and Find Full Text PDFEnhanced motivated behavior mediated by pharmacological targeting of the FGF14/Na1.6 complex in nucleus accumbens neurons.
Nat Commun
January 2025
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, TX, USA.
Protein/protein interactions (PPI) play crucial roles in neuronal functions. Yet, their potential as drug targets for brain disorders remains underexplored. The fibroblast growth factor 14 (FGF14)/voltage-gated Na channel 1.
View Article and Find Full Text PDFTrace Cu Doping Enabled High Rate and Long Cycle Life Sodium Iron Phosphate Cathode for Sodium-Ion Batteries.
ACS Nano
January 2025
School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
NaFe(PO)(PO) (NFPP) is currently receiving a lot of attention, as it combines the advantages of NaFePO and NaFePO in terms of cost, energy density, and cycle stability. However, the issues of intrinsic poor electronic conductivity and difficult high-purity preparation may impede its practical application. Herein, the pivotal role of Cu doping in strengthening the polyanion structure and improving its electrochemical properties is comprehensively investigated.
View Article and Find Full Text PDFTargeting ion channels: innovative approaches to combat cancer drug resistance.
Theranostics
January 2025
School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Article Synopsis
- Ion channels play a crucial role in regulating ion flow across cell membranes and have become a key focus in cancer therapy due to their influence on cancer cell behaviors like proliferation and drug resistance.
- Dysregulated ion channels, such as abnormal sodium and potassium channels, are linked to chemotherapy sensitivity, while calcium channels contribute to resistance in specific lung cancer types, and ferrous ions can make breast cancer cells more susceptible to treatment.
- The review highlights the potential of using ion channel blockers or modulators to improve the effectiveness of anticancer drugs and presents a hopeful strategy for addressing drug resistance in cancer treatments.
The modulation of calcium and chloride channels induces cardiomyocytes from human pluripotent stem cells.
Int J Biol Sci
January 2025
Faculty of Health Sciences, University of Macau, Taipa, Macau.
Ion channels play a crucial role in cardiac functions, and their activities exhibit dynamic changes during heart development. However, the precise function of ion channels in human heart development remains elusive. In this study, we utilized human embryonic stem cells (hESCs) as a model to mimic the process of human embryonic heart development.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!