AI Article Synopsis
- Personalized treatment options for patients with diffuse large B-cell lymphoma (DLBCL) are being developed, with a focus on specific treatments for different patient groups.
- Caracciolo et al. investigate UMG1, a specific part of the CD43 protein, as a potential therapeutic target and find encouraging results with an Anti-UMG1-antibody in preclinical studies.
- The study highlights the use of a bispecific T-cell engager (BTCE) that redirects T-cell activity to effectively target DLBCL.
Article Abstract
Personalized treatment options for subsets of patients with DLBCL are beginning to emerge. Caracciolo et al. explore UMG1, an epitope of CD43 as a potential target for certain patients with DLBCL, and demonstrate promising preclinical activity of an Anti-UMG1-antibody. Commentary on: Caracciolo et al. UMG1/CD3ε-bispecific T-cell engager (BTCE) redirects T-cell cytotoxicity against diffuse large B-cell lymphoma (DLBCL). Br J Haematol 2024;204:555-560.
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| http://dx.doi.org/10.1111/bjh.19195 | DOI Listing |
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