AI Article Synopsis
- The study evaluated humoral (antibody) and cellular immune responses in 22 patients before and after their third and fourth vaccinations.
- Results showed that antibody responses improved as B-cell depletion resolved, and cellular responses increased steadily, indicating that repetitive vaccinations may help these patients until their B-cells recover.
Article Abstract
Patients treated with anti-CD20 antibodies for haematological disorders have insufficient immune responses to mRNA COVID-19 vaccines; however, relevant sequential data are lacking. We sequentially evaluated the humoral and cellular immune responses in 22 patients who had received anti-CD20 antibodies within 12 months before the first vaccination, before and after the third and fourth vaccinations. Humoral responses improved gradually, along with the resolution of B-cell depletion. A steady increase was noted in cellular responses, regardless of the B-cell status. Our findings suggest the potential benefit of repeated vaccinations in these patients until B-cell recovery is confirmed while enhancing cellular responses.
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| http://dx.doi.org/10.1111/bjh.19207 | DOI Listing |
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