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| http://dx.doi.org/10.1503/cmaj.230734 | DOI Listing |
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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Cerebral amyloid angiopathy (CAA), defined as the accumulation of amyloid in cerebral blood vessels causing alterations in the blood brain barrier (BBB) and the gliovascular unit, occurs in over 85% of Alzheimer's disease (AD) cases, positioning CAA as one of the strongest vascular contributors to age-related cognitive decline. However, the specific mechanisms in the microvasculature that become altered due to amyloid deposition and its downstream effects on the brain are complex and incompletely understood. A spatial transcriptomic analysis comparing pathways affected in the gliovascular niche differently in the presence of vascular amyloid could provide critical insight into the mechanisms underlying cerebrovascular changes involved in the deposition of Amyloid in the cerebrovasculature.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Center for Neurodegenerative Disease Research, PHILADELPHIA, PA, USA; University of Pennsylvania, Philadelphia, PA, USA.
Background: Neurodegenerative diseases with the presence of tau pathology account for 90% of dementia in human patients, the most common of which is Alzheimer's disease (AD). Although therapeutic approaches targeting tau and tau pathology are still under development, it remains unclear how tau targeting antibodies can inhibit the development of tau pathology.
Method: We hypothesize tau antibodies enter neurons and inhibit the seeding of tau pathology without direct interaction to the pathogenic tau seeds.
A smart probe for detection of sugar markers for applications in gastrointestinal barrier dysfunction.
Biosens Bioelectron
December 2024
Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford, Department of Radiology, Stanford School of Medicine, Stanford University, Palo Alto, CA, 94304, USA. Electronic address:
Article Synopsis
- Gastrointestinal (GI) barrier dysfunction is a critical early indicator of multiple complex diseases, but current testing methods for saccharide molecules used to assess this function are expensive and time-consuming.
- A new one-component system utilizing a naphthyl-pyridine core and boronic acid receptor has been developed for the early detection of saccharide biomarkers like lactulose, which indicates GI barrier issues.
- The innovative design incorporates a scalable 96-well format with gold nanoparticles and combines plasmonics and fluorescence for sensitive lactulose quantification, aiming to create an affordable and portable diagnostic tool for routine GI permeability testing.
Enhancing Leadership and Management Skills in Public Health: Insights from the Public Health Management and Leadership Training Program in Uttar Pradesh, India.
J Healthc Leadersh
December 2024
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Article Synopsis
- In Indian states, many public health programs are led by clinicians lacking formal leadership training, prompting Uttar Pradesh to launch a Public Health Management and Leadership program for mid-career medical officers to enhance their administrative skills.
- The training included essential skills such as leadership, communication, and problem-solving through in-person sessions and hands-on projects, with participant feedback measured via Kirkpatrick's model and statistical analyses showing notable but moderate improvements in learning outcomes.
- Despite high satisfaction with the program, participants struggled to apply management concepts due to contextual limitations and barriers like resource constraints and gender stereotypes, suggesting a need for additional training in finance and human resources.
WeARTolerance: Evaluating the impact of an arts-based program to reduce mental health-related stigma in young people.
PLoS One
December 2024
HEI-Lab: Digital Human-Environment Interaction Labs, Lusófona University, Lisbon, Portugal.
The stigma surrounding mental health remains a significant barrier to help-seeking and well-being in youth populations. The invisibility of mental health issues highlights the critical need for improved knowledge and stigma reduction, underscoring the urgency of tackling this issue. Arts-based interventions have shown promise in addressing stigma, yet comprehensive longitudinal studies in community settings are limited.
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