AI Article Synopsis
- Legacy PFAS like PFOS and PFOA are being replaced by alternatives such as GenX, which are thought to be less toxic and bioaccumulative.
- This study investigates the impact of PFAS on gray treefrog tadpoles and finds that exposure during the larval stage affects growth even after metamorphosis.
- Interestingly, GenX showed more significant impacts on terrestrial performance than PFOA, indicating a need for further research on how PFAS interacts with environmental stressors like pathogens.
Article Abstract
Legacy polyfluoroalkyl substances (PFAS) [perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA)] are being replaced by various other fluorinated compounds, such as hexafluoropropylene oxide dimer acid (GenX). These alternatives are thought to be less bioaccumulative and, therefore, less toxic than legacy PFAS. Contaminant exposures occur concurrently with exposure to natural stressors, including the fungal pathogen (). Despite evidence that other pollutants can increase the adverse effects of on anurans, no studies have examined the interactive effects of and PFAS. This study tested the growth and developmental effects of PFOS, PFOA, and GenX on gray treefrog () tadpoles, followed by a challenge after metamorphosis. Despite PFAS exposure only occurring during the larval stage, carry-over effects on growth were observed post metamorphosis. Further, PFAS interacted with exposure to influence growth; -exposed animals had significantly shorter SVL [snout-vent length (mm)] with significantly increased body condition, among other time-dependent effects. Our data suggest that larval exposure to PFAS can continue to impact growth in the juvenile stage after exposure has ended. Contrary to predictions, GenX affected terrestrial performance more consistently than its legacy congener, PFOA. Given the role of in amphibian declines, further investigation of interactions of PFAS with and other environmentally relevant pathogens is warranted.
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| http://dx.doi.org/10.1021/acs.est.3c03191 | DOI Listing |
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