AI Article Synopsis
- Ten sesquiterpene lactones from Anvillea garcinii were tested for their anti-inflammatory effects using myeloperoxidase (MPO) activity and a rodent paw swelling model.
- Seven specific compounds demonstrated notable anti-inflammatory properties by reducing paw edema and inhibiting MPO activity.
- The study suggests that while the α-methylene γ-lactone structure isn't always linked to anti-inflammatory effects, incorporating proline in the lactone ring enhances the interaction with MPO isoenzymes, improving their efficacy.
Article Abstract
Ten sesquiterpene lactones isolated from Anvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-inflammatory potential by myeloperoxidase (MPO) activity assignment, and mice paw swelling model. 3α,4α-10β-trihydroxy-8α-acetyloxyguaian-12,6α-olide (1), epi-vulgarin (3), 9a-hydroxyparthenolide (4), garcinamine C (7), garcinamine D (8), garcinamine E (9), and 4, 9-dihydroxyguaian-10(14)-en-12-olide (10) showed explicit anti-inflammatory activity in rodent paw edema and MPO assignment. The findings of this study showed that the α-methylene γ-lactone moiety does not always guarantee an anti-inflammatory effect, but the presence of proline at the C of the lactone ring improves the binding of sesquiterpene lactones with MPO isoenzymes, resulting in a more potent inhibition.
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| http://dx.doi.org/10.1007/s10787-023-01375-x | DOI Listing |
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