AI Article Synopsis
- Nearly 3% of the proteins in the bacteria causing human tuberculosis are lipoproteins, which play key roles in the disease's development.
- The authors review and categorize these lipoproteins based on their functions, such as transporting compounds, aiding in cell envelope synthesis, and contributing to defense mechanisms.
- The analysis also shows that over 40% of these lipoproteins are glycosylated, indicating a complex role in mycobacterial biology.
Article Abstract
Almost 3% of the proteins of (), the main causative agent of human tuberculosis, are lipoproteins. These lipoproteins are characteristic of the mycobacterial cell envelope and participate in many mechanisms involved in the pathogenesis of . In this review, the authors provide an updated analysis of lipoproteins and categorize them according to their demonstrated or predicted functions, including transport of compounds to and from the cytoplasm, biosynthesis of the mycobacterial cell envelope, defense and resistance mechanisms, enzymatic activities and signaling pathways. In addition, this updated analysis revealed that at least 40% of lipoproteins are glycosylated.
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| http://dx.doi.org/10.2217/fmb-2023-0088 | DOI Listing |
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