Structural health monitoring (SHM) has attracted significant attention over the past two decades due to its ability to provide real-time insight into the condition of structures. Despite the development of several SHM systems for long-span bridges, which play a crucial role in the assessment of these structures, studies focusing on short- or middle-span bridges remain scarce. This research paper presents an efficient and practical bridge monitoring and warning system established on a middle-span bridge, a key crossroad bridge located in Shenzhen. The monitoring system consists of sensors and measuring points that collect a substantial amount of data, enabling the close monitoring of various operational indicators to facilitate the early detection of threshold exceedances. Based on this system, the subtle condition of the bridge can be evaluated, and the operational condition of the bridge can be studied through the comparative analysis of the collected data. Over four months of monitoring, data including the strain and creep of the main beam, the strain and settlement of piers and the crack width of the bridge body are observed. Furthermore, the real-time operational status of the bridge is analyzed and evaluated through the combination of the collected data and the structural finite element model.
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http://dx.doi.org/10.3390/s23218702 | DOI Listing |
Blood Adv
January 2025
Vanderbilt University Medical Center, Nashville, Tennessee, United States.
In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight kininogen (HK) to release bradykinin, which contributes to regulation of blood vessel tone and permeability. Plasma FXII is normally in a "closed" conformation that limits activation by PKa.
View Article and Find Full Text PDFJMIR Pediatr Parent
January 2025
School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China.
Background: Previous research suggested that parent-administered pediatric tuina could improve symptoms of attention-deficit/hyperactivity disorder (ADHD), such as sleep quality and appetite.
Objective: This study aimed to explore the experiences and perceptions of parents administering pediatric tuina to school-aged children with ADHD in Hong Kong.
Methods: This qualitative study was embedded in a pilot randomized controlled trial on parent-administered pediatric tuina for improving sleep and appetite in school-aged children diagnosed with ADHD.
J Med Internet Res
January 2025
Department High-Tech Business and Entrepreneurship Section, Industrial Engineering and Business Information Systems, University of Twente, Enschede, Overijssel, Netherlands.
Health recommender systems (HRS) have the capability to improve human-centered care and prevention by personalizing content, such as health interventions or health information. HRS, an emerging and developing field, can play a unique role in the digital health field as they can offer relevant recommendations, not only based on what users themselves prefer and may be receptive to, but also using data about wider spheres of influence over human behavior, including peers, families, communities, and societies. We identify and discuss how HRS could play a unique role in decreasing health inequities.
View Article and Find Full Text PDFJ Health Serv Res Policy
January 2025
Associate Professor, Exeter Collaboration for Academic Primary Care, University of Exeter Medical School, Exeter, UK.
Objective: Digital services in primary care are becoming more common, yet access to and use of services can create inequities. Our aim was to explore the drivers, priorities, and evolving policy context influencing digital facilitation in primary care as reported by national, regional and local level stakeholders in England.
Methods: We conducted online semi-structured qualitative interviews with stakeholders, including those in NHS England organisations, local commissioners for health care, statutory and third sector organisations, those working within the research community, and digital platform providers.
Proc Natl Acad Sci U S A
February 2025
Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
The ionizable lipid component of lipid nanoparticle (LNP) formulations is essential for mRNA delivery by facilitating endosomal escape. Conventionally, these lipids are synthesized through complex, multistep chemical processes that are both time-consuming and require significant engineering. Furthermore, the development of new ionizable lipids is hindered by a limited understanding of the structure-activity relationships essential for effective mRNA delivery.
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