AI Article Synopsis
- Pyrazine is a nitrogen-containing six-membered ring, and many of its derivatives have important biological activities.
- A review of studies published from 2000 to September 2023 focuses on natural product derivatives that include pyrazine, assessing their structure, biological effects, and mechanisms.
- The findings suggest that pyrazine derivatives show diverse biological activities like anti-inflammatory and anticancer effects, often with improved potency and reduced toxicity compared to their original compounds.
Article Abstract
Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its derivatives are biologically active compounds. References have been downloaded through Web of Science, PubMed, Science Direct, and SciFinder Scholar. The structure, biological activity, and mechanism of natural product derivatives containing pyrazine fragments reported from 2000 to September 2023 were reviewed. Publications reporting only the chemistry of pyrazine derivatives are beyond the scope of this review and have not been included. The results of research work show that pyrazine-modified natural product derivatives have a wide range of biological activities, including anti-inflammatory, anticancer, antibacterial, antiparasitic, and antioxidant activities. Many of these derivatives exhibit stronger pharmacodynamic activity and less toxicity than their parent compounds. This review has a certain reference value for the development of heterocyclic compounds, especially pyrazine natural product derivatives.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649211 | PMC |
| http://dx.doi.org/10.3390/molecules28217440 | DOI Listing |
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