AI Article Synopsis
- Ascending thoracic aortic aneurysms are a major health risk, often leading to fatal outcomes like rupture or dissection, particularly in developed countries.
- This review focuses on how understanding these aneurysms could reduce their associated health risks, especially their complex relationship with atherosclerosis.
- The authors suggest various mechanisms, such as matrix metalloproteinases and transforming growth factor-β, that might explain the connection between aneurysms and lower rates of heart disease indicators like carotid thickness and LDL levels.
Article Abstract
Ascending thoracic aortic aneurysms may be fatal upon rupture or dissection and remain a leading cause of death in the developed world. Understanding the pathophysiology of the development of ascending thoracic aortic aneurysms may help reduce the morbidity and mortality of this disease. In this review, we will discuss our current understanding of the protective relationship between ascending thoracic aortic aneurysms and the development of atherosclerosis, including decreased carotid intima-media thickness, low-density lipoprotein levels, coronary and aortic calcification, and incidence of myocardial infarction. We also propose several possible mechanisms driving this relationship, including matrix metalloproteinase proteins and transforming growth factor-β.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650782 | PMC |
| http://dx.doi.org/10.3390/ijms242115640 | DOI Listing |
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