AI Article Synopsis
- Antibiotic resistance is a critical issue in healthcare and agriculture, with a focus on using biocompatible and biodegradable substances like curcumin supported by the Next Generation EU platform.
- Encapsulating curcumin in nanobubbles (NBs) enhances its solubility, stability, and antibacterial effectiveness, particularly when activated by specific wavelengths of light.
- The study finds that oxygen-loaded curcumin nanobubbles (Curc-Oxy-CS-NBs) significantly improve antibacterial properties, showing a drastic reduction in minimum inhibitory concentration (MIC) and effectively killing bacteria through mechanisms like ROS-induced membrane leakage.
Article Abstract
In both healthcare and agriculture, antibiotic resistance is an alarming issue. Biocompatible and biodegradable ingredients (e.g., curcumin) are given priority in "green" criteria supported by the Next Generation EU platform. The solubility and stability of curcumin would be significantly improved if it were enclosed in nanobubbles (NB), and photoactivation with the correct wavelength of light can increase its antibacterial efficacy. A continuous release of curcumin over a prolonged period was provided by using innovative chitosan-shelled carriers, i.e., curcumin-containing nanobubbles (Curc-CS-NBs) and oxygen-loaded curcumin-containing nanobubbles (Curc-Oxy-CS-NBs). The results demonstrated that after photoactivation, both types of NBs exhibited increased effectiveness. For , the minimum inhibitory concentration (MIC) for Curc-CS-NBs remained at 46 µg/mL following photodynamic activation, whereas it drastically dropped to 12 µg/mL for Curc-Oxy-CS-NBs. shows a decreased MIC for Curc-CS-NB and Curc-Oxy-CS-NB (23 and 46 µg/mL, respectively). All bacterial strains were more effectively killed by NBs that had both oxygen and LED irradiation. A combination of Curc-Oxy-CS-NB and photodynamic stimulation led to a killing of microorganisms due to ROS-induced bacterial membrane leakage. This approach was particularly effective against . In conclusion, this work shows that Curc-CS-NBs and Curc-Oxy-CS-exhibit extremely powerful antibacterial properties and represent a potential strategy to prevent antibiotic resistance and encourage the use of eco-friendly substitutes in agriculture and healthcare.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10650092 | PMC |
| http://dx.doi.org/10.3390/ijms242115595 | DOI Listing |
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