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Filename: controllers/Detail.php
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Function: _error_handler
File: /var/www/html/index.php
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Filename: controllers/Detail.php
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Background: Several tumor-associated macrophages (TAMs) have shown promise as prognosticators in cancer. Our aim was to validate the importance of TAMs in malignant pleural mesothelioma (MPM) using a two-stage design.
Methods: We explored The Cancer Genome Atlas (TCGA-MESO) to select immune-relevant macrophage genes in MPM, including M1/M2 markers, as a discovery cohort. This computational cohort was used to create a multiplex immunofluorescence panel. Moreover, a cohort of 68 samples of MPM in paraffin blocks was used to validate the macrophage phenotypes and the co-localization and spatial distribution of these immune cells within the TME and the stromal or tumor compartments.
Results: The discovery cohort revealed six immune-relevant macrophage genes (, , , , , ), and complementary genes were differentially expressed by M1 and M2 phenotypes with distinct roles in the tumor microenvironment and were associated with the prognosis. In addition, immune-suppressed MPMs with increased enrichment of CD68, CD86, and CD163 genes and high densities of M2 macrophages expressing CD163 and CD206 proteins were associated with worse overall survival (OS). Interestingly, below-median distances from malignant cells to specific M2a and M2c macrophages were associated with worse OS, suggesting an M2 macrophage-driven suppressive component in these tumors.
Conclusions: The interactions between TAMs in situ and, particularly, CD206 macrophages are highly relevant to patient outcomes. High-resolution technology is important for identifying the roles of macrophage populations in tissue specimens and identifying potential therapeutic candidates in MPM.
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http://dx.doi.org/10.3390/cancers15215116 | DOI Listing |
Environ Sci Process Impacts
December 2024
Anhui Bossco Environmental Protection Technology Co., Ltd, Ningguo, Anhui, 242301, China.
Contamination of heavy metals (HMs) has caused increasing concern due to their ecological toxicities and difficulties in degradation. The transport, retention, and release of HMs in porous media are highly related to their environmental fate and risk to groundwater. Column transport experiments and numerical simulations were conducted to investigate the retention and release behaviors of Cu, Pb, Cd, and Zn in the presence and absence of kaolin under varying ionic strengths and cation types.
View Article and Find Full Text PDFWater Res X
January 2025
Department of Systemic Environmental Biotechnology, Helmholtz Centre for Environmental Research-UFZ, Permoserstrasse 15 04318 Leipzig, Germany.
Due to accelerating climate change and the need for new development to accommodate population growth, adaptation of urban drainage systems has become a pressing issue in cities. Questions arise whether decentralised urban drainage systems are a better alternative to centralised systems, and whether Nature Based Solutions' (NBS) multifunctionality also brings economic benefits. This research aims to develop spatio-economic scenarios to support cities in increasing their resilience to urban flooding with NBS.
View Article and Find Full Text PDFStud Mycol
December 2024
Environmental Microbiology Laboratory, Department of Agricultural Biological Chemistry, College of Agriculture & Life Sciences, Chonnam National University, Gwangju 61186, South Korea.
The is a group of ancient fungi with global distribution. In the current study we accessed mucoralean fungi isolated from two countries on opposite sides of the Earth and in different hemispheres: South Korea and Brazil. isolates were obtained from freshwater, soil, invertebrates, and fruit seeds and identified using phenotypic techniques combined with the DNA sequence data.
View Article and Find Full Text PDFEcol Evol
December 2024
Department of Conservation Biology and Global Change Estación Biológica de Doñana, EBD-CSIC Sevilla Spain.
Long-term studies depicting the multicontinental invasion trajectories of species are often constrained by the scarcity of documented records, especially for invertebrates. The red swamp crayfish, (Decapoda: Cambaridae), stands out as an uncommon example of hypersuccessful invasive species with a well-known invasion history at both regional and global levels. This allows for the use of its records to track distribution dynamics and bioclimatic preferences over time.
View Article and Find Full Text PDFMass Spectrom (Tokyo)
December 2024
Department of Chemistry and Materials Engineering, Kansai University, 3-3-35 Yamate-cho, Suita, Osaka 564-8680, Japan.
In this study, we employed platinum-assisted surface-assisted laser desorption/ionization mass spectrometry imaging (MSI) (Pt-SALDI-MSI) to detect and visualize the spatial distribution of antioxidant additives and organic dyes in polystyrene films undergoing photodegradation. In traditional matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS), matrix-derived ion peaks often obscure signals from low-molecular-weight analytes. Pt-SALDI-MSI, which utilizes inorganic nanoparticles instead of an organic matrix, enables the interference-free analysis of low-molecular-weight compounds, thereby addressing the limitation of traditional MALDI-MS.
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