AI Article Synopsis
- Hypothyroidism and hyperthyroidism increase the risk of cardiovascular issues, with both conditions showing a U-shaped relationship with thyroid-stimulating hormone levels.
- Several known mechanisms connect thyroid disorders to cardiovascular diseases, including endothelial dysfunction, blood pressure changes, and inflammation.
- Research on how these thyroid conditions specifically affect peripheral arterial disease hasn't been thoroughly explored in clinical trials.
Article Abstract
Hypothyroidism and hyperthyroidism, both overt and subclinical, are associated with increased risk of cardiovascular morbidity and mortality. The association between thyroid-stimulating hormone levels and cardiovascular risk has been demonstrated in large epidemiological studies and meta-analyses and is now considered a U-shaped curve. Several pathophysiological mechanisms linking thyroid and cardiovascular disease are known; however, specific clinical complications of peripheral arterial disease as endpoints of clinical trials have not been adequately investigated. The potential mechanisms linking hypothyroidism and peripheral arterial disease are endothelial dysfunction, blood pressure changes, dyslipidemia, and low-grade systemic inflammation. The potential mechanisms linking hyperthyroidism and peripheral arterial disease are hyperdynamic circulation, elevated systolic blood pressure, hypercoagulability, and possibly increased arterial inflammation.
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| http://dx.doi.org/10.2174/0115701611271284231105063148 | DOI Listing |
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