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Sudden Vision Loss: A Diagnostic Approach.
Am Fam Physician
January 2025
Western University Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Vision loss affects more than 7 million Americans and impacts quality of life, independence, social functioning, and overall health. Common and dangerous conditions causing sudden vision loss include acute angle-closure glaucoma, retinal detachment, retinal artery occlusion, giant cell arteritis, and optic neuritis. Acute angle-closure glaucoma features ocular pain, headache, and nausea; treatment includes pilocarpine eye drops, oral or intravenous acetazolamide, and intravenous mannitol.
View Article and Find Full Text PDFIntestinal distension induced by luminal D-allulose promotes GLP-1 secretion in male rats.
Endocrinology
January 2025
Laboratory of Nutritional Biochemistry, Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan.
The secretion of glucagon-like peptide-1 (GLP-1) is promoted by various nutrients, and glucose and fructose stimulate GLP-1 secretion via intracellular metabolism. D-Allulose (allulose), a non-metabolizable epimer of D-fructose, is also effective in stimulating GLP-1 secretion, although its underlying mechanism remains unclear. We previously observed intestinal distension after the oral administration of allulose, accompanied by increased GLP-1 secretion in rats, possibly because of the low or slow absorbability of allulose.
View Article and Find Full Text PDFCompounded glucagon-like peptide-1 receptor agonists for weight loss: the direct-to-consumer market in Colorado.
J Pharm Policy Pract
December 2024
Department of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Background: High prices and other access barriers have contributed to the rise of a market for compounded glucagon-like peptide-1 receptor agonists for weight loss in the United States. This market has not been systematically studied. We conducted a pilot study to assess the prevalence, characteristics, and advertising content of direct-to-consumer providers of compounded glucagon-like peptide-1 products for weight loss in Colorado.
View Article and Find Full Text PDFExploring the causal relationship between inflammatory cytokines, metabolites, and Behcet's syndrome: Mendelian randomization.
Cytokine
February 2025
Department of Periodontology and Oral Mucosa, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; Heilongjiang Provincial Key Laboratory of Hard Tissue Development and Regeneration, The Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:
Article Synopsis
- Behcet's syndrome causes oral ulcers and involves complex inflammatory processes; this study investigates the relationship between inflammatory cytokines, metabolites, and the disease's development using Mendelian randomization.
- The research analyzed associations between 91 cytokines and 553 metabolites through genetic variants (SNPs) and employed various statistical tests to ensure reliability.
- Five substances, including specific interleukins and a metabolite, were found to be causally related to the syndrome, providing potential markers for diagnosis and treatment, but more research is needed to confirm their efficacy as targets for therapy.
A Case Report of Meningitis Caused by Biovar 3.
Infect Drug Resist
December 2024
State International Joint Research Center for Animal Health Breeding, College of Animal Science and Technology, Shihezi University, Shihezi, People's Republic of China.
Background: Brucellosis, a major endemic disease in northern China, is contracted by zoonosis of . We report a case of meningitis caused by biovar 3.
Case Presentation: A 46-year-old man was hospitalized at a local medical facility due to symptoms of fever, soreness, and weakness on April 16, 2021.
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