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Cell type mapping reveals tissue niches and interactions in subcortical multiple sclerosis lesions.
Nat Neurosci
December 2024
Department of Neurology, Division of Neuroimmunology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Inflammation is gradually compartmentalized and restricted to specific tissue niches such as the lesion rim. However, the precise cell type composition of such niches, their interactions and changes between chronic active and inactive stages are incompletely understood.
View Article and Find Full Text PDFCircadian cilia transcriptome in mouse brain across physiological and pathological states.
Mol Brain
September 2024
Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University of California, 356A Med Surge II, Irvine, CA, 92697-4625, USA.
Primary cilia are dynamic sensory organelles that continuously undergo structural modifications in response to environmental and cellular signals, many of which exhibit rhythmic patterns. Building on our previous findings of rhythmic cilia-related gene expression in diurnal primates (baboon), this study extends the investigation to the nocturnal mouse brain to identify circadian patterns of cilia gene expression across brain regions. We used computational techniques and transcriptomic data from four publicly available databases, to examine the circadian expression of cilia-associated genes within six brain areas: brainstem, cerebellum, hippocampus, hypothalamus, striatum, and suprachiasmatic nucleus.
View Article and Find Full Text PDFSUB-immunogold-SEM reveals nanoscale distribution of submembranous epitopes.
Nat Commun
September 2024
Department of Otolaryngology-Head & Neck Surgery, School of Medicine, 240 Pasteur Drive, Stanford University, Stanford, CA, 94305, USA.
Electron microscopy paired with immunogold labeling is the most precise tool for protein localization. However, these methods are either cumbersome, resulting in small sample numbers and restricted quantification, or limited to identifying protein epitopes external to the membrane. Here, we introduce SUB-immunogold-SEM, a scanning electron microscopy technique that detects intracellular protein epitopes proximal to the membrane.
View Article and Find Full Text PDFSpecific Mitotic Events Drive Cytoskeletal Remodeling Required for Left-Right Organizer Development.
bioRxiv
October 2024
Department of Biology, Syracuse University, Syracuse, 13244 USA.
Cellular proliferation is vital for tissue development, including the Left-Right Organizer (LRO), a transient organ critical for establishing the vertebrate LR body plan. This study investigates cell redistribution and the role of specific progenitor cells in LRO formation, focusing on cell lineage and behavior. Using zebrafish as a model, we mapped all mitotic events in Kupffer's Vesicle (KV), revealing an FGF-dependent, anteriorly enriched mitotic pattern.
View Article and Find Full Text PDFA multi-trait GWAS identifies novel genes influencing albuminuria.
Nephrol Dial Transplant
December 2024
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
Article Synopsis
- - This study investigated the genetic factors associated with albuminuria, a condition linked to kidney and heart disease, by utilizing a multi-trait analysis method to examine kidney-related traits from the Taiwan Biobank data.
- - Researchers identified 15 genetic loci related to urine albumin levels, including 12 that were previously unknown, and found a strong connection between these loci and the presence of microalbuminuria.
- - The results highlight the potential role of primary cilia in kidney function and suggest the need for further research into identified genes to develop strategies for reducing albuminuria.
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