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| http://dx.doi.org/10.1073/pnas.2206230120 | DOI Listing |
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Unlabelled: Proteins commonly self-assemble to create liquid or solid condensates with diverse biological activities. The mechanisms of assembly are determined by each protein's sequence and cellular context. We previously developed distributed amphifluoric FRET (DAmFRET) to analyze sequence determinants of self-assembly in cells.
View Article and Find Full Text PDFDevelopment and validation of career sustainability scale for mid-career employees.
Front Psychol
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Department of Education, Chung-Ang University, Seoul, Republic of Korea.
A sustainability perspective on careers builds a resilient career system by simultaneously considering individual's current career needs and long-term career outcomes. The individual career agent's strategy for achieving a sustainable career is a powerful approach to career development in an environment where an individual's proactive career competencies are emphasized. Mid-career individuals, especially those facing career transitions, need to increase their sustainability by maintaining, renewing, and developing their current careers.
View Article and Find Full Text PDFHigh nature value farming systems in Europe: A dataset encompassing the environmental impact assessment of farms and extensive ruminant food products.
Data Brief
February 2025
Department of Agricultural Sciences, Faculty of Agriculture and Forestry, University of Helsinki, Latokartanonkaari 5, 00014, Finland.
High Nature Value (HNV) farming systems occur in areas where the major land use is agriculture and are characterized by their significance in promoting biodiversity and ecosystem services due to their extensive land use. Despite their importance for ecological and socio-economic resilience of rural regions, these systems are often overlooked in Life Cycle Assessment (LCA) studies due to challenges in data compilation, especially from small local farms and because of the diversity of production. To address this gap, we established an international collaborative network across Europe, involving professionals directly engaged with farmers, farmer associations, and researchers to collect data on HNV farms employing a developed questionnaire examining inputs and outputs, farm structures, and herd characteristics.
View Article and Find Full Text PDFLiquid-liquid phase separation driven by charge heterogeneity.
Commun Phys
December 2024
Institut für Theoretische Physik, TU Wien, Wiedner Hauptstraße 8-10, A-1040 Wien, Austria.
Despite the intrinsic charge heterogeneity of proteins plays a crucial role in the liquid-liquid phase separation (LLPS) of a broad variety of protein systems, our understanding of the effects of their electrostatic anisotropy is still in its early stages. We approach this issue by means of a coarse-grained model based on a robust mean-field description that extends the DLVO theory to non-uniformly charged particles. We numerically investigate the effect of surface charge patchiness and net particle charge on varying these features independently and with the use of a few parameters only.
View Article and Find Full Text PDFA scoping review on the obstacles faced by beta thalassemia major patients in Pakistan- Matter of policy investment.
AIMS Public Health
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Community health science, Aga Khan University Karachi, Pakistan.
Beta-thalassemia major (β-TM) is a genetic disorder, prevalent especially in the Mediterranean region, Southeast Asia, and the Indian subcontinent. With improvements in management over the years, β-TM has transitioned from a fatal childhood disease to a chronic condition. However, in Pakistan, there is still a lack of a comprehensive national policy and strategic plan, which has resulted in a growing number of β-TM patients, placing a substantial burden on individuals and the national healthcare system.
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