Existing wisdom holds that secrecy is burdensome and fatiguing. However, past research has conflated secrecy with the kinds of adverse events that are often kept secret. As a result, it is unclear whether secrecy is inherently depleting, or whether these consequences vary based on the underlying meaning of the secret. We resolve this confound by examining the consequences of positive secrets. In contrast to the prior research, five experiments (N = 2,800) find that positive secrets increase feelings of energy, relative to (a) content-matched positive non-secrets, (b) other pieces of unknown positive information, and (c) other kinds of secrets. Importantly, these energizing effects of positive secrets were independent of positive affect. We further found that positive secrets are energizing because, compared to other kinds of secrets, people keep them for more intrinsically than extrinsically motivated reasons. That is, these secrets are more freely chosen, more consistent with personal values, and more motivated by internal desires (than by external pressures). Using both measures and manipulations of these motivations, we found that a motivational mechanism helps explain the energizing effect of positive secrets. The present results offer new insights into secrecy, how people respond to positive life events, and the subjective experiences of vitality and energy. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
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http://dx.doi.org/10.1037/pspa0000352 | DOI Listing |
Int J Gynaecol Obstet
December 2024
Department of Obstetrics and Gynecology, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Objective: To determine the safety, tolerance, and adherence to self-administered intravaginal 5% fluorouracil (5FU) cream as adjuvant therapy following cervical intraepithelial neoplasia grade 2 or 3 (CIN2/3) treatment among women living with HIV (WLWH) in Kenya.
Methods: A phase I pilot trial was performed among 12 WLWH in Kenya, aged 18-49 years between March 2023 and February 2024 (ClinicalTrial.gov NCT05362955).
Adv Sci (Weinh)
December 2024
Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Promoting tumor cell senescence arrests the cell cycle of tumor cells and activates the immune system to eliminate these senescent cells, thereby suppressing tumor growth. Nevertheless, PD-L1 positive senescent tumor cells resist immune clearance and possess the ability to secret various cytokines and inflammatory factors that stimulate the growth of tumor cells. Consequently, drugs capable of both triggering senescence in tumor cells and concurrently diminishing the expression of PD-L1 to counteract immune evasion are urgently needed.
View Article and Find Full Text PDFJAMA Netw Open
December 2024
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Pak J Med Sci
December 2024
Mallahat Abdul Baseer, Final Year MBBS, Khyber Medical College, Peshawar, Pakistan.
Background & Objective: It's no secret that medical students have access to a plethora of medical literature, which can make it challenging to determine the right sources and how to cover them effectively using various study habits and strategies. Our objective was to determine the association of study habits (time and location), study duration, study strategies, and study sources with academic performance.
Methods: It was a cross-sectional study conducted in six Medical Colleges in Peshawar, Pakistan between 13 April 2023 to 13 Jun 2023.
Front Microbiol
November 2024
Dapeng New District Center for Disease Control and Prevention, Shenzhen, Guangdong, China.
() is a major food-borne pathogen which causes human gastroenteritis. Since the characteristics of remain unknown, 220 isolates selected from clinical and environmental samples in Dapeng of Shenzhen were tested for the presence of two hemolysin-expressing genes and . Among 27 clinical isolates, 26 carrired the gene, and the other one carried both and genes, however neither genes were detected in environmental isolates.
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