AI Article Synopsis
- Sulfoxonium ylide is used to facilitate the C-H allylation of arenes by employing strained vinyl carbo/heterocycles as substitutes for allyl groups.
- This process involves a sequential activation of C-H and C-C/heteroatom bonds.
- Key advantages include a wide range of applicable substrates, co-catalysis, high selectivity, and the ability to modify drugs in later development stages.
Article Abstract
Sulfoxonium ylide chelation-assisted C-H allylation of arenes has been accomplished utilizing strained vinyl carbo/heterocycles as the allyl surrogates sequential C-H and C-C/het bond activation. Broad substrate scope, Co-catalysis, selectivity, and late-stage drug mutation are the important practical features.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d3cc04507b | DOI Listing |
Publication Analysis
Top Keywords
c-h allylation
8
bond activation
8
expedient c-h
4
allylation sulfoxonium
4
sulfoxonium ylides
4
ylides merging
4
merging c-h
4
c-h c-c/c-het
4
c-c/c-het bond
4
activation sulfoxonium
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!