Pulsar Timing Array experiments probe the presence of possible scalar or pseudoscalar ultralight dark matter particles through decade-long timing of an ensemble of galactic millisecond radio pulsars. With the second data release of the European Pulsar Timing Array, we focus on the most robust scenario, in which dark matter interacts only gravitationally with ordinary baryonic matter. Our results show that ultralight particles with masses 10^{-24.0} eV≲m≲10^{-23.3} eV cannot constitute 100% of the measured local dark matter density, but can have at most local density ρ≲0.3 GeV/cm^{3}.
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http://dx.doi.org/10.1103/PhysRevLett.131.171001 | DOI Listing |
Acta Neurol Belg
December 2024
Lamezia Terme Hospital, Catanzaro, Italy.
Curr Issues Mol Biol
December 2024
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Canine mammary carcinomas (CMCs) represent the most prevalent form of cancer in female dogs, characterized by a high incidence and mortality rate. C6 ceramide is recognized for its multifaceted anti-cancer properties, yet its specific influence on CMCs remains to be elucidated. Long noncoding RNAs (lncRNAs), now recognized as functional "dark matter" in precision oncology, are particularly intriguing, with 44% of canine lncRNAs exhibiting tissue-specific expression.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
Department of Chemical Sciences and Center for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER) Kolkata, Mohanpur 741246, West Bengal, India.
Triple-negative breast cancer (TNBC) poses significant treatment challenges due to its high metastasis, heterogeneity, and poor biomarker expression. The N-terminus of an octapeptide NAPVSIPQ () was covalently coupled to a carboxylic acid derivative of Ru(2,2'-bipy) () to synthesize an N-stapled short peptide-Rubpy conjugate (). This photosensitizer (PS) was utilized to treat TNBC through microtubule (MT) targeted chemotherapy and photodynamic therapy (PDT).
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Department of Physics, Kyungpook National University, Daegu 41566, Republic of Korea.
We give for the first time theoretical estimates of unknown rare electron-capture (EC) decay branchings of ^{44}Ti, ^{57}Co, and ^{139}Ce, relevant for searches of (exotic) dark-matter particles. The nuclear-structure calculations have been done exploiting the nuclear shell model with well-established Hamiltonians and an advanced theory of β decay. In the absence of experimental measurements of these rare branches, these estimates are of utmost importance for terrestrial searches of dark-matter particles, such as axionic dark matter in the form of axionlike particles, anapole dark matter, and dark photons in nuclear transitions.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Department of Astronomy, Cornell University, Ithaca, New York 14853, USA.
We present a new perturbative full-shape analysis of BOSS galaxy clustering data, including the full combination of the galaxy power spectrum and bispectrum multipoles, baryon acoustic oscillations, and cross-correlations with the gravitational lensing of cosmic microwave background measured from Planck. Assuming the ΛCDM model, we constrain the matter density fraction Ω_{m}=0.3138±0.
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