AI Article Synopsis
- The study focuses on the piriform cortex (PC) and its connectivity, especially in relation to epilepsy, using high-quality data from the human connectome project.
- Researchers analyzed structural connectivity by tracing the PC in 20 subjects and using advanced imaging techniques.
- The results showed strongest connections between the PC and the insula, particularly the posterior long gyri, which could help in understanding and treating temporo-insular epilepsy.
Article Abstract
Background And Objectives: The piriform cortex (PC) is part of the primary olfactory network in humans. Recent findings suggest that it plays a role in pathophysiology of epilepsy. Therefore, studying its connectivity can further our understanding of seizure propagation in epilepsy. We aimed to explore the structural connectivity of PC using high-quality human connectome project data coupled with segmentation of PC on anatomic MRI.
Methods: Twenty subjects were randomly selected from the human connectome project database, and PC was traced on each hemisphere. Probabilistic whole-brain tractography was then used to visualize PC connectivity.
Results: The strongest connectivity was noted between PC and ipsilateral insula in both hemispheres. Specifically, the posterior long gyrus of each insula was predominantly connected to PC. This was followed by connections between PC and basal ganglia as well as orbital frontal cortices.
Conclusion: The PC has the strongest connectivity with the insula bilaterally. Specifically, the posterior long gyri of insula have the strongest connectivity. This finding may provide additional insight for localizing and treating temporo-insular epilepsy.
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| http://dx.doi.org/10.1227/neu.0000000000002756 | DOI Listing |
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