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Discovery of new VEGFR-2 inhibitors and apoptosis inducer-based thieno[2,3-]pyrimidine. | LitMetric
VEGFR-2 is a key regulator of cancer cell proliferation, migration and angiogenesis. Development of thieno[2,3-]pyrimidine derivatives as potential anti-cancer agents targeting VEGFR-2. Seven and nine studies were conducted. Compound demonstrated strong anticancer potential, boosting apoptosis based on VEGFR-2 inhibition. It arrested the S phase of the cell cycle and upregulated the apoptotic factors. Docking and molecular dynamics simulation studies confirm the stability of the VEGFR-2- complex and suggest that these compounds have good binding affinities to VEGFR-2. In addition, the drug-likeness was confirmed. Thieno[2,3-]pyrimidines, particularly compound , has good anticancer effects and may contribute to the development of new anticancer therapies.
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