Introduction: Matrix metalloproteinases enzymes (MMPs) can degrade the hybrid layer which can cause failure of composite restorations. Chlorhexidine gluconate 2% can reduce MMPs activity and increase the bond strength of the resin to dentin.
Purpose: This study aims to determine the role of the duration of chlorhexidine gluconate 2% application on shear bond strength of a total-etch bonding agent.
Methods: A total of 36 freshly extracted maxillary premolars were removed occlusally by one-third of the crown using a carborundum disc until the dentin was exposed. Specimens were divided into four groups n(9). The dentin surfaces were etched for 5s. Group A is the control group. In group B, chlorhexidine gluconate 2% was applied for 30s. In group C, chlorhexidine gluconate 2% was applied for 60s. In group D, chlorhexidine gluconate 2% was applied for 90s. The universal adhesive was applied afterwards and then followed by composite to the dentin surface. All specimens were stored in artificial saliva at 37°C for 24 hours. The shear bond strength was tested using a universal testing machine.
Results: There was an increase in the shear bond strength of the bonding agent along with the additional application duration of chlorhexidine gluconate 2%. All groups gave higher MPa values than the control group. The shear bond strength in group A (control) was 12.64 MPa; Group B (30s of chlorhexidine) was 16.93 MPa; Group C (60s chlorhexidine) was 18.23 MPa; group D (90s of chlorhexidine) was 18.47MPa.
Conclusion: Duration of chlorhexidine gluconate 2% application affects the shear bond strength of the bonding agent with the total-etch system. The effective duration of chlorhexidine gluconate 2% for the restorative procedure is 60 seconds.
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http://dx.doi.org/10.2147/CCIDE.S432480 | DOI Listing |
J Arthroplasty
January 2025
Department of Orthopedic Surgery, Mayo Clinic, 200 First Street S.W., Rochester, MN, 55905.
Background: Native and periprosthetic joint infections are devastating conditions fraught with patient morbidity and mortality. Aseptic and septic joints are often debrided and irrigated to decrease bacterial loads when preventing or treating infection. However, the effect of clinically used irrigation solutions on the native cellular components of the synovial joint is unknown.
View Article and Find Full Text PDFNeurosurg Rev
January 2025
Neurosurgery Division, Department of Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
Ventriculoperitoneal (VP) shunting is frequently associated with complications of which shunt-related infections are the most common. However, controversies still exist regarding the underlying factors. This study comparing peri-operative skin preparation agents was aimed at determining which factors among previously documented determinants of shunt infection are implicated in our practice setting.
View Article and Find Full Text PDFVet World
November 2024
Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
Background And Aim: Skin antisepsis plays a crucial role in pre-operative skin preparation, with chlorhexidine gluconate and alcohol being historically the preferred choice. However, concerns have risen regarding the development of bacterial resistance to chlorhexidine. Polyhexamethylene biguanide (PHMB) combined with Tris-ethylenediaminetetraacetic acid (Tris-EDTA) has recently emerged as a skin and wound antiseptic.
View Article and Find Full Text PDFJ Vet Med Sci
January 2025
Faculty of Veterinary Medicine, Okayama University of Science.
In recent years, the importance of using local disinfectants instead of systemic antibiotics for the treatment of infectious skin diseases to prevent the emergence of resistant bacteria has become widely recognized. Chlorhexidine gluconate (CHG) is commonly used in veterinary antibacterial shampoos; however, the daily topical application of diluted CHG solutions has also been adopted. Despite its widespread use, few studies have investigated the effects of CHG on the canine skin barrier.
View Article and Find Full Text PDFActa Cir Bras
January 2025
Universidade Federal Rural de Pernambuco - Programa de Pós-Graduação em Medicina Veterinária - Departamento de Morfologia e Fisiologia Animal - Recife (PE) - Brazil.
Purpose: To evaluate whether the effectiveness of topical antiseptic solutions in restoring skin continuity solutions is related to their antimicrobial action or to their action in maintaining moisture, in dogs undergoing elective surgeries.
Methods: Forty dogs, 20 males and 20 females, underwent orchiectomy and oophorectomy, respectively. Thereafter, the animals were allocated into four groups (n = 5) and treated with different topical solutions: polyhexanide 0.
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