AI Article Synopsis
- Drug-resistant mental disorders, especially treatment-resistant depression, are significant challenges in modern medicine, prompting exploration of new treatment methods.
- Transcranial magnetic stimulation (TMS) and rapid-acting antidepressants like ketamine show strong effectiveness in treating these disorders, but not all patients respond adequately.
- Recent studies suggest that combining TMS and ketamine may enhance results; this review aims to consolidate findings and explore the mechanisms for increased effectiveness in combined treatments.
Article Abstract
Drug-resistant mental disorders, particularly treatment-resistant depression, pose a significant medical and social problem. To address this challenge, modern psychiatry is constantly exploring the use of novel treatment methods, including biological treatments, such as transcranial magnetic stimulation (TMS), and novel rapid-acting antidepressants, such as ketamine. While both TMS and ketamine demonstrate high effectiveness in reducing the severity of depressive symptoms, some patients still do not achieve the desired improvement. Recent literature suggests that combining these two methods may yield even stronger and longer-lasting results. This review aims to consolidate knowledge in this area and elucidate the potential mechanisms of action underlying the increased efficacy of combined treatment, which would provide a foundation for the development and optimization of future treatment protocols.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637948 | PMC |
| http://dx.doi.org/10.3389/fnins.2023.1267647 | DOI Listing |
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