Background: Lumbar spinal stenosis (LSS) is a common pain condition that causes lumbar back pain, radiating leg pain, and possible functional impairment. is an emerging minimally invasive treatment for LSS. It is an image-guided percutaneous procedure designed to debulk hypertrophied ligamentum flavum. However, the exact short- and long-term efficacy, safety profile, indication criteria, and certain procedure details reported in medical literature vary.
Objective: This narrative review was to elucidate efficacy, safety profile, certain procedure details, advantages, and limitations of
Study Design: This is a narrative review.
Setting: All included articles are clinic trials including analytic studies and descriptive studies.
Methods: PubMed, Cochrane Library, and Scopus were searched. Only clinical trials of procedure were included. Information of indications, contraindications, VAS scores, ODI scores, effective rate, efficacy durations, and certain procedure details was focused on.
Results: According to the literature, for the procedure, the VAS score could be reduced from a pre-treatment level of 6.3-9.6 to a post-treatment level of 2.3-5.8. The ODI score could be reduced from a pre-treatment level of 38.8-55.3 to a post-treatment level of 27.4-39.8. The effective rate of the procedure was reported to be 57.1%-88%. A 2-year postoperative stability of efficacy was also supported. One RCT study testified superior efficacy of over epidural steroid injection.
Limitations: There is few high-quality literature in the review. Moreover, the long-term efficacy of cannot be revealed according to the current literature.
Conclusion: Based on the reviewed literature, is an effective and safe procedure. can reduce pain intensity and improve functional status significantly. Therefore, it is a preferable option for LSS patients who failed conservative treatments, but not for those who require immediate invasive decompression surgery.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10637222 | PMC |
http://dx.doi.org/10.2147/JPR.S428112 | DOI Listing |
JAMA Cardiol
December 2024
The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Importance: Drug-coated balloon (DCB) angioplasty has emerged as an alternative to drug-eluting stent (DES) implantation for percutaneous coronary intervention (PCI) in patients with coronary in-stent restenosis (ISR) as well as de novo coronary artery disease.
Observations: DCBs are balloons coated with antiproliferative agents and excipients, whose aim is to foster favorable vessel healing after appropriate lesion preparation. By providing homogeneous antiproliferative drug delivery in the absence of permanent foreign body implantation, DCBs offer multiple advantages over DES, including preservation of vessel anatomy and function and positive vessel remodeling.
Mater Horiz
December 2024
Department of Process Engineering and Chemical Technology, Faculty of Chemistry, Gdansk University of Technology, 80-233 Gdansk, Poland.
A porous, photocatalytically active, and water-stable composite membrane has been developed based on Cu-NH-MIL-125(Ti), a titanium-based metal-organic framework (MOF) and PVDF polymeric matrix. To tune the structural and functional properties of the PVDF/MOF composites, the loading degree of the MOF within the polymer was systematically varied. The most effective performance of the composite material was achieved with a 10% wt/wt loading of MOF into the PVDF matrix.
View Article and Find Full Text PDFMicrobiol Spectr
December 2024
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang, China.
Unlabelled: SCovid v2.0 (http://bio-annotation.cn/scovid or http://bio-computing.
View Article and Find Full Text PDFPediatr Pulmonol
December 2024
Curriculum in Toxicology and Environmental Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Background: E-cigarette, or vaping products produce an aerosol by heating nicotine, or cannabis including tetrahydrocannabinol (THC) and cannabidiol (CBD), mixed with other chemicals that help make the aerosol. They are increasingly popular among teenagers and young adults, with a 2023 survey reporting that 2.13 million middle and high school students in the United States used e-cigarettes within the last 30 days.
View Article and Find Full Text PDFBiosci Rep
December 2024
Universidade Nova de Lisboa Instituto de Tecnologia Quimica e Biologica Antonio Xavier, Oeiras e São Julião da Barra, Portugal.
Multicentre redox proteins participate in diverse metabolic processes, such as redox shuttling, multielectron catalysis, or long-distance electron conduction. The detail in which these processes can be analysed depends on the capacity of experimental methods to discriminate the multiple microstates that can be populated while the protein changes from the fully reduced to the fully oxidized state. The population of each state depends on the redox potential of the individual centres and on the magnitude of the interactions between the individual redox centres with their neighbours.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!