AI Article Synopsis
- DrugBank, launched in 2006, is a leading resource for drug and pharmaceutical information, receiving over 30 million views annually.
- The recent update, DrugBank 6.0, has significantly expanded its database, increasing the number of FDA approved drugs by 72% and investigational drugs by 38%.
- Enhancements include thousands of new pathways for drug mechanisms, improved datasets for 11,891 drugs, and added experimental data like MS/MS spectra for nearly 9,500 small molecule drugs, making it more valuable for researchers across multiple fields.
Article Abstract
First released in 2006, DrugBank (https://go.drugbank.com) has grown to become the 'gold standard' knowledge resource for drug, drug-target and related pharmaceutical information. DrugBank is widely used across many diverse biomedical research and clinical applications, and averages more than 30 million views/year. Since its last update in 2018, we have been actively enhancing the quantity and quality of the drug data in this knowledgebase. In this latest release (DrugBank 6.0), the number of FDA approved drugs has grown from 2646 to 4563 (a 72% increase), the number of investigational drugs has grown from 3394 to 6231 (a 38% increase), the number of drug-drug interactions increased from 365 984 to 1 413 413 (a 300% increase), and the number of drug-food interactions expanded from 1195 to 2475 (a 200% increase). In addition to this notable expansion in database size, we have added thousands of new, colorful, richly annotated pathways depicting drug mechanisms and drug metabolism. Likewise, existing datasets have been significantly improved and expanded, by adding more information on drug indications, drug-drug interactions, drug-food interactions and many other relevant data types for 11 891 drugs. We have also added experimental and predicted MS/MS spectra, 1D/2D-NMR spectra, CCS (collision cross section), RT (retention time) and RI (retention index) data for 9464 of DrugBank's 11 710 small molecule drugs. These and other improvements should make DrugBank 6.0 even more useful to a much wider research audience ranging from medicinal chemists to metabolomics specialists to pharmacologists.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10767804 | PMC |
| http://dx.doi.org/10.1093/nar/gkad976 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multi-angle acquisition and 3D composite reconstruction for organ-targeted PET using planar detectors.
Med Phys
December 2024
Department of Physics, Lakehead University, Thunder Bay, Ontario, Canada.
Background: This study investigates a multi-angle acquisition method aimed at improving image quality in organ-targeted PET detectors with planar detector heads. Organ-targeted PET technologies have emerged to address limitations of conventional whole-body PET/CT systems, such as restricted axial field-of-view (AFOV), limited spatial resolution, and high radiation exposure associated with PET procedures. The AFOV in organ-targeted PET can be adjusted to the organ of interest, minimizing unwanted signals from other parts of the body, thus improving signal collection efficiency and reducing the dose of administered radiotracer.
View Article and Find Full Text PDFIncreasing Reachability in Robotic Ultrasound Through Base Placement and Tool Design.
Int J Med Robot
February 2025
Insitute for Robotics and Kognitive Systems, University of Luebeck, Luebeck, Germany.
Background: Robotic ultrasound visualises internal organs in real-time for various medical applications without the harm of X-rays. The ultrasound probe is attached to the robot's end effector using custom-developed probe holders. This paper analyzes the impact of different probe holder geometries on the robot's base placement and reachability.
View Article and Find Full Text PDFPostural control patterns in gravid women-A systematic review.
PLoS One
December 2024
Section of Rehabilitation in Orthopaedics, Clinical Rehabilitation Institute, Faculty of Motor Rehabilitation, University of Physical Education, Krakow, Poland.
Background: Postural stability is essential for functional independence in the pregnant population. The contradictions between existing studies and the lack of consistent characteristics in the strategies used by pregnant women for postural control demonstrate the need for further investigation.
Objectives: The aim was to review the available literature on postural strategies throughout pregnancy in both static and dynamic conditions and to provide an assessment of the quality of these studies in terms of methodological issues to identify the reasons for the inconsistencies in findings between research centers.
Changes in daily stress reactivity and changes in physical health across 18 years of adulthood.
Ann Behav Med
December 2024
Department of Human Development and Family Studies, Pennsylvania State University, University Park, PA, 16803, United States.
Background: Stress plays a pivotal role in physical health. Although many studies have linked stress reactivity (daily within-person associations between stress exposure and negative affect) to physical health outcomes, we know surprisingly little about how changes in stress reactivity are related to changes in physical health.
Purpose: The current study examines how change in stress reactivity over 18 years is related to changes in functional health and chronic health conditions.
Myelofibrosis (MF) is a myeloproliferative neoplasm that was most commonly treated with hydroxyurea (HU) prior to approval of ruxolitinib (RUX), now the standard of care. Factors that influence changes in MF treatment in real-world settings are not well understood. The METER study (NCT05444972) was a multi-country retrospective chart review of MF treatment patterns, treatment effectiveness, and healthcare resource utilization.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!