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Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma. | LitMetric

AI Article Synopsis

  • - The study investigates the gene expression profiles of dogs with high-grade B-cell lymphoma who underwent chemotherapy, focusing on those that either relapsed early or achieved remission.
  • - Researchers analyzed 25 cases and identified 179 differentially expressed genes (DEGs), highlighting specific genes related to immune signaling and tumor interactions that differed between dogs that relapsed and those that did not.
  • - Notably, genes like CCL4 were downregulated in the relapse group, while genes such as CD3E, ITK, and LAT were upregulated, suggesting that tumor and immune cell interactions play a crucial role in the effectiveness of chemotherapy.

Article Abstract

Although chemotherapy using CHOP-based protocol induces remission in most cases of canine multicentric high-grade B-cell lymphoma (mhBCL), some cases develop early relapse during the first induction protocol. In this study, we examined the gene expression profiles of canine mhBCL before chemotherapy and investigated their associations with early relapse during the first whole CHOP-based protocol. Twenty-five cases of mhBCL treated with CHOP-based protocol as first induction chemotherapy were included in this study. Sixteen cases completed the first whole CHOP-based protocol without relapse (S-group), and nine developed relapse during the chemotherapy (R-group). RNA-seq was performed on samples from neoplastic lymph nodes. Differentially expressed genes (DEGs) were extracted by the comparison of gene expression profiles between S- and R-groups, and the differences in the expression levels of these genes were validated by RT-qPCR. Extracted 179 DEGs included the genes related to chemokine CC motif ligand, T-cell receptor signaling pathway, and PD-L1 expression and PD-1 checkpoint pathway. We focused on chemokine CC motif ligand, and CCL4 was confirmed to be significantly downregulated in the R-group (P=0.039). We also focused on the genes related to T-cell signaling pathway, and CD3E (P=0.039), ITK (P=0.023), and LAT (P=0.023) genes were confirmed to be significantly upregulated in the R-group. The current results suggest that both changes in tumor cells and the interactions between tumor cells and immune cells are associated with the efficacy of the chemotherapy for first remission induction.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10849849PMC
http://dx.doi.org/10.1292/jvms.23-0269DOI Listing

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