AI Article Synopsis
- A investigation of Selaginella tamariscina resulted in the isolation of 17 new selaginellin derivatives, which were tested for their effects on breast cancer cells.
- The dimeric selaginellin 17 showed significant anti-cancer activity against MDA-MB-231 cells, being four times more potent than the commonly used drug 5-FU.
- Further studies revealed that selaginellin 17 can cause cell cycle arrest at the G2/M phase and promote cell death by increasing reactive oxygen species (ROS) levels.
Article Abstract
A phytochemical investigation of Selaginella tamariscina led to the isolation of 17 selaginellin derivatives. Their inhibitory activities against breast cancer cells were screened, and preliminary structure-activity relationships were also established. Among them, dimeric selaginellin 17 showed potential activity against MDA-MB-231 cells with an IC value of 3.2 ± 0.1 μM, corresponding to 4-fold higher potency than the reference compound 5-FU (IC 14.8 ± 0.2 μM). Mechanistic studies indicated that 17 could cause G2/M phase arrest in MDA-MB-231 cells and induce apoptosis accompanied by increased ROS levels.
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| http://dx.doi.org/10.1016/j.phytochem.2023.113919 | DOI Listing |
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