Planning road safety interventions on large road networks implies several layers of complexity in the decision-making process. In fact, the following simultaneous problems should be addressed: estimating safety performances on the different road elements of the network, identifying sites showing high potential for improvement with respect to reference values, defining the possible types of safety measures to be implemented and their anticipated effect on traffic safety, limiting the number of interventions given fixed budget constraints. This study proposes an integrated multi-layer framework which takes into account the above-defined problems into a single optimization procedure which provides the number and type of safety interventions to be implemented over a wide road network composed of different categories of road elements. The proposed framework is based on the following peculiar aspects: the potential for safety improvement is quantitatively assessed based on the estimation of safety performances for each road category, a bi-level thresholding process integrated in the optimization process is used to highlight sites for interventions, the anticipated outcome of safety measures is quantitatively assessed as well through available crash reduction factors. The proposed methodology is applied to a case study which analyzes a sample of real roads belonging to a province-wide road network composed of various road elements (i.e., different categories of segments and intersections), under different budget constraints. Results demonstrate the applicability and flexibility of the proposed approach, which could be used for planning purposes, independently of the particular geographic location. Clearly, the approach is valid at the planning stage, given that several details of the different layers of analysis are necessarily simplified, while they should be studied in detail at the single intervention project stage.
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http://dx.doi.org/10.1016/j.aap.2023.107374 | DOI Listing |
Adv Mater
January 2025
Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, Wisconsin, 53706, USA.
Unconventional spin-orbit torques arising from electric-field-generated spin currents in anisotropic materials have promising potential for spintronic applications, including for perpendicular magnetic switching in high-density memory applications. Here, all the independent elements of the spin torque conductivity tensor allowed by bulk crystal symmetries for the tetragonal conductor IrO are determined via measurements of conventional (in-plane) anti-damping torques for IrO thin films in the high-symmetry (001) and (100) orientations. It is then tested whether rotational transformations of this same tensor can predict both the conventional and unconventional anti-damping torques for IrO thin films in the lower-symmetry (101), (110), and (111) orientations, finding good agreement.
View Article and Find Full Text PDFMethodsX
June 2025
Department of Computer Engineering, Pimpri Chinchwad College of Engineering, Nigdi, Pune 411044, India.
Recent advancements in artificial intelligence (AI) have increased interest in intelligent transportation systems, particularly autonomous vehicles. Safe navigation in traffic-heavy environments requires accurate road scene segmentation, yet traditional computer vision methods struggle with complex scenarios. This study emphasizes the role of deep learning in improving semantic segmentation using datasets like the Indian Driving Dataset (IDD), which presents unique challenges in chaotic road conditions.
View Article and Find Full Text PDFBurns Trauma
January 2025
The Orthopaedic Center, The Affiliated Wenling Hospital of Wenzhou Medical University (The First People's Hospital of Wenling), 333 Chuanan Road, Chengxi Street, Wenling City, Zhejiang Province 317500, China.
Background: Neuronal structure is disrupted after spinal cord injury (SCI), causing functional impairment. The effectiveness of exercise therapy (ET) in clinical settings for nerve remodeling post-SCI and its underlying mechanisms remain unclear. This study aims to explore the effects and related mechanisms of ET on nerve remodeling in SCI rats.
View Article and Find Full Text PDFGenome Biol
January 2025
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK.
Background: East African cichlid fishes have diversified in an explosive fashion, but the (epi)genetic basis of the phenotypic diversity of these fishes remains largely unknown. Although transposable elements (TEs) have been associated with phenotypic variation in cichlids, little is known about their transcriptional activity and epigenetic silencing. We set out to bridge this gap and to understand the interactions between TEs and their cichlid hosts.
View Article and Find Full Text PDFBMC Cancer
January 2025
Department of Anesthesiology, the First Affiliated Hospital of Dalian Medical University, 222, Zhongshan Road, Xigang District, Dalian, 116011, Liaoning, China.
Background: Lidocaine is a traditional local anesthetic, which has been reported to trigger apoptosis through the mitochondrial pathway, independent of death receptor signaling. Cuproptosis is a copper triggered mitochondrial cell death mode. In this study, we explored the biological effects of lidocaine on cuproptosis in Hep-2 cells and studied the relevant mechanisms.
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