AI Article Synopsis
- This study focused on 51 patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK-MG) from various centers in Japan to analyze their clinical features and outcomes.
- The average age when symptoms began was 37 years, with a notable majority of the patients being female; nearly all patients presented with generalized and bulbar symptoms.
- Around half of the patients were categorized as having refractory myasthenia gravis, showing more severe symptoms and requiring higher doses of oral prednisolone compared to those who were not refractory, suggesting a need for more effective treatments.
Article Abstract
This study included 51 patients with muscle-specific kinase antibody-positive myasthenia gravis (MuSK-MG) from a Japanese multicenter survey to examine clinical features and outcomes. Median onset age was 37 years and female predominance was observed. All patients developed generalized symptoms and almost all (50/51) patients had bulbar symptoms. About half of the patients met the criteria for refractory MG. The refractory group had a lower age of onset, higher severity scores, and higher maximum daily doses of oral prednisolone compared to the nonrefractory group. The outcomes for MuSK-MG patients in Japan are not favorable, indicating the need for more aggressive treatment.
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| http://dx.doi.org/10.1016/j.jneuroim.2023.578241 | DOI Listing |
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