Selinexor: Changing the paradigm in patients with TP53 wild-type endometrial cancer?

Med

Comprehensive Cancer Centers of Nevada - Central Valley, 3730 S Eastern Avenue, Las Vegas, NV 89169, USA; Kirk Kerkorian School of Medicine at University of Nevada, Las Vegas (UNLV), 4505 S. Maryland Pkwy, Las Vegas, NV 89154, USA; Touro University Nevada, 874 American Pacific Dr, Henderson, NV 89014, USA. Electronic address:

Published: November 2023

Recurrent endometrial cancer (EC) remains a therapeutic challenge despite advancements in personalized medicine. SIENDO trial showed the potential clinical benefit of selinexor in patients with TP53 wild-type advanced/recurrent EC. The quest for novel therapeutic avenues and approaches continues as researchers seek a glimmer of hope in an area of uncertainty.

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Source
http://dx.doi.org/10.1016/j.medj.2023.10.005DOI Listing

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