While new immunotherapies have revolutionized the field of oncology, they have been limited by their inability to distinguish between cancerous cells and healthy HSPCs. Work by Casirati et al. and Wellhausen et al. in epitope editing antigens commonly expressed on AML and HSPCs has unlocked several new targets for immunotherapies.
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| http://dx.doi.org/10.1016/j.medj.2023.10.004 | DOI Listing |
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Biomarkers.
Alzheimers Dement
December 2024
Division of Nuclear Medicine, Geneva University Hospitals, Geneva, Switzerland.
Background: Substantial variability in tau accumulation patterns in Alzheimer's disease (AD) population has now become accepted. Subtype and Stage Inference (SuStaIn) has distinguished four distinct spatiotemporal trajectories of tau pathology: limbic (S1), medial temporal lobe-sparing (S2), posterior (S3), and lateral temporal (S4). A visual method to validate and identify them is a requirement for their clinical translation.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
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Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, London, United Kingdom.
Background: Neuropsychiatric symptoms (NPS) are behavioural and psychological manifestations frequently present in dementia and mild cognitive impairment (MCI). NPS are known to be associated with adverse health, cognitive and functional outcomes and increasing needs for hospitalisation and institutionalisation. It is understood that MCI may be an intermediate stage between healthy and dementia states.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Division of Nuclear Medicine, Geneva University Hospitals, Geneva, Switzerland.
Background: Substantial variability in tau accumulation patterns in Alzheimer's disease (AD) population has now become accepted. Subtype and Stage Inference (SuStaIn) has distinguished four distinct spatiotemporal trajectories of tau pathology: limbic (S1), medial temporal lobe-sparing (S2), posterior (S3), and lateral temporal (S4). A visual method to validate and identify them is a requirement for their clinical translation.
View Article and Find Full Text PDFMultimodal analgesia with parasternal plane block protocol within an enhanced recovery after cardiac surgery program decreases opioid use.
JTCVS Open
December 2024
Department of Cardiac Surgery, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France.
Objective: This study investigated the efficacy of a multimodal analgesia (MMA) with an opioid-sparing strategy, incorporating a parasternal plane block (PPB) within a systematic standardized Enhanced Recovery After Surgery (ERAS) program for patients undergoing elective cardiac surgery.
Methods: From 2015 to 2021, 3153 patients underwent elective coronary artery bypass grafting and/or valve procedures. Patients were dichotomized by the presence or absence of an ERAS program including a perioperative MMA with an opioid-sparing approach and PPB protocols.
Enhanced Recovery After Surgery (ERAS) cardiac turnkey order set for perioperative pain management in cardiac surgery: Proceedings from the American Association for Thoracic Surgery (AATS) ERAS Conclave 2023.
JTCVS Open
December 2024
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, Md.
Objective: Optimal perioperative pain management is an essential component of perioperative care for the cardiac surgical patient. This turnkey order set is part of a series created by the Enhanced Recovery After Surgery Cardiac Society, first presented at the Annual Meeting of The American Association for Thoracic Surgery in 2023. Several guidelines and expert consensus documents have been published to provide guidance on pain management and opioid reduction in cardiac surgery.
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