AI Article Synopsis
- Antibiotic resistance is a significant global public health issue, prompting interest in phage therapy as an alternative treatment for multidrug-resistant bacterial infections.
- Challenges in bacteriophage therapy include developing effective drug formulations for consistent phage delivery.
- Nano-emulsion encapsulation is highlighted as a promising method to enhance phage stability and efficacy, ensuring targeted delivery in therapeutic applications.
Article Abstract
Antibiotic resistance has become the major concern for global public health. Phage therapy is being considered as an alternative for antibiotics to treat the multidrug resistant bacterial infections. Bacteriophage therapeutic developments has faced many challenges, including the drug formulations for sustainable phage delivery. The nano-emulsion platform has been described as the best approach to retain phage efficacy, shelf life and stability. Encapsulated phage drugs ensure stable delivery of phages to the target site and integrate in the system. In this review, our main focus is on the nano-emulsion encapsulation of bacteriophages and its effects towards the phage therapeutic development.
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| http://dx.doi.org/10.1016/j.biologicals.2023.101725 | DOI Listing |
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