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Evaluation of post-COVID mortality risk in cases classified as severe acute respiratory syndrome in Brazil: a longitudinal study for medium and long term.
Front Med (Lausanne)
December 2024
Programa Academico de Tuberculose/Faculdade de Medicina/Instituto de Doenças do Torax/Hospital Universitário Clementino Fraga Filho/ Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Background: There are few studies in the literature evaluating post-COVID mortality in Brazil, along medium and long term, especially in those who presented severe clinical disease.
Objective: This study aims to investigate the factors associated with post-COVID mortality of severe acute respiratory syndrome (SARS) cases from 2020 to 2023 in Brazil, along medium and long term.
Methods: Retrospective cohort study using notification data of SARS classified as COVID-19 from the Brazilian National Information System, "Sistema de Vigilância Epidemiológica (SIVEP)," during the period 2020 to 2023.
The Continuous Fragility Index of Outcomes in Rotator Cuff Repair Augmentation Randomized Trials: A Systematic Review.
J Shoulder Elbow Surg
December 2024
Division of Orthopaedics, Department of Surgery, McMaster University, Hamilton, ON, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. Electronic address:
Background: Symptomatic rotator cuff tears often undergo surgical repair, which may be paired with various augmentation strategies to enhance structural healing rates. While many randomized controlled trials (RCTs) evaluate augmentation techniques, the statistical robustness of many findings in these studies is unknown. This systematic review aims to evaluate the continuous fragility index (CFI) of RCTs on augmentation techniques for rotator cuff repairs.
View Article and Find Full Text PDFBeyond the Usual Significance: Fragility Indices of Randomized Controlled Trials in Top General Orthopaedic Journals.
J Am Acad Orthop Surg
December 2024
From the Joint Reconstruction Research Center, Tehran University of Medical Sciences, Tehran, Iran (Poursalehian, Sahebi, Tajvidi, and Sabaghian), the Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran (Sahebi), the Student Research Committee, Faculty of Medicine, Abadan University of Medical Sciences, Abadan, Iran (Tajvidi), the School of Medicine, Iran University of Medical sciences, Tehran, Iran (Sabaghian), the Orthopedic Surgery Research Center (OSRC), Sina University Hospital, Tehran University of Medical Sciences, Tehran, Iran (Asgari), the Department of Orthopaedic Surgery, Nationwide Children's Hospital, Columbus, OH (Tabaie), the Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada (Bhandari), the Division of Orthopedic Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada (Bhandari), and the International Center for Limb Lengthening, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, MD (Hoveidaei).
Introduction: Understanding the reliability of outcomes in randomized controlled trials (RCTs) is crucial, as standard metrics, such as P-value do not fully capture result fragility. This led to the adoption of specific indices: the fragility index (FI), which measures the strength of trial through significant results by calculating the minimum number of patient status changes from nonevent to event required to make the results statistically insignificant; reverse fragility index (RFI), used for insignificant results; and continuous fragility index (CFI), which acts similar to FI for significant continuous outcomes. The objective is to assess the robustness of orthopaedics RCTs using these indices across leading orthopaedic journals.
View Article and Find Full Text PDFCurrent and future perspectives on pregnancy and lactation-associated osteoporosis.
Front Endocrinol (Lausanne)
December 2024
Section of Endocrinology & Investigative Medicine, Imperial College London, London, United Kingdom.
Normal pregnancy and lactation have a marked physiological impact on maternal bone metabolism. This impact is usually temporary and reversible, but some women sustain fragility fractures whilst pregnant or lactating, termed pregnancy and lactation-associated osteoporosis (PLO). These fractures have severe negative consequences on their quality of life, at what is a crucial stage in a mother's life.
View Article and Find Full Text PDFRandomized trials evaluating volar locking plates against casting of distal radius fractures are statistically fragile: A systematic review.
J Orthop
June 2025
Department of Orthopaedic Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Introduction: Despite randomized controlled trials (RCTs) largely supporting volar locking plates (VLPs) for the management of distal radius fractures (DRFs), surgeons often opt for non-invasive interventions such as casting. This study used the fragility index (FI), reverse fragility index (rFI), and fragility quotient (FQ) to assess the statistical robustness of RCTs assessing the efficacy of VLP in DRF management.
Methods: PubMed, Embase, and MEDLINE were queried for RCTs evaluating VLP versus casting for DRFs published from January 1st, 2000-June 30, 2024.
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