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Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy.
Int J Nanomedicine
November 2024
Department of Nuclear Medicine, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Article Synopsis
- Gold nanoparticles (Au NPs) can be easily labeled with radioactive iodine, making them promising tools for tumor treatment and diagnosis in cancer therapy.
- This study evaluated the stability and effectiveness of iodine-adsorbed Au NPs in targeting tumors, using various conditions to analyze their performance.
- The results indicate that these iodine-adsorbed Au NPs are stable, effective in inhibiting tumor cells, and show therapeutic potential when injected into tumors in living subjects.
Tumoricidal Activity and Side Effects of Radiolabeled Anti-NCAM [I]-Iodine-ERIC1 in Neuroblastoma-Bearing Mice.
Int J Mol Sci
October 2024
Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Article Synopsis
- Preliminary research found that a radioactive antibody called [I]I-ERIC1 specifically targets neuroblastoma tumor cells in mice, showing significant accumulation in tumors.
- Researchers aimed to assess the safety and effectiveness of this antibody in treating neuroblastoma by testing various doses on healthy and tumor-bearing mice.
- Results indicated that the optimal dose for treatment was between 1.8-2.5 MBq per animal, which improved survival rates significantly while ensuring minimal side effects at lower doses.
Localization and Tumor Growth Inhibition of I-131-Labeled Monoclonal Antibody ERIC1 in a Subcutaneous Xenograft Model of Small Cell Lung Cancer in SCID Mice.
Int J Mol Sci
October 2024
Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
This study evaluates the efficacy of [I]I-ERIC1 in targeting and inhibiting the growth of SCLC tumors in mice, focusing on tumor accumulation and regression and potential side effects. NCAM-positive NCI-H69 SCLC cells were implanted in CB 17 SCID mice, and [I]I-ERIC1 biokinetics were measured in organs and tissues at four post-injection time points (24, 72, 96, and 120 h). The experimental series compared tumor growth, survival, and changes in blood counts among three treatment groups (1, 2, or 3 MBq) and a control group, with treatments initiated either two or five days post implantation.
View Article and Find Full Text PDFCharacteristics of exposure to radioactive iodine during a nuclear incident.
Radiol Oncol
December 2024
Division of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Article Synopsis
- * Contamination sources include air, food, and water, making proximity to nuclear incidents a significant factor in exposure risk, especially in iodine-deficient areas.
- * To mitigate these risks, ensuring sufficient iodine supply is vital, and the use of potassium iodide tablets can protect the thyroid by blocking radioactive iodine absorption, but this protection is time-sensitive and mainly recommended for individuals under 40.
Responsive and traceless assembly of iron nanoparticles and I labeled radiopharmaceuticals for ferroptosis enhanced radio-immunotherapy.
Biomaterials
February 2025
State Key Laboratory of Natural Medicines, Key Laboratory of Drug Quality Control and Pharmacovigilance, School of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. Electronic address:
Ferroptosis is an iron-dependent form of programmed cell death with the potential to reverse traditional cancer therapy resistance. The combination of ferroptosis with chemotherapy, photodynamic therapy and X-ray therapy has demonstrated remarkably improved therapeutic efficiency. Radiopharmaceutical therapy (RPT) is an emerging approach that achieves precise radiation to diseased tissues via radionuclide delivery.
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