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Two highly conjugated ergosterols from the fungus and their anti-inflammatory activity. | LitMetric

Two highly conjugated ergosterols from the fungus and their anti-inflammatory activity.

J Asian Nat Prod Res

School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.

Published: January 2024

AI Article Synopsis

  • Two new types of ergosterols, named psathrosterols A and B, have been discovered from a fungus.
  • The chemical structures and configurations of these compounds were determined using advanced techniques like spectroscopy and X-ray diffraction.
  • Psathrosterols A and B demonstrated significant inhibition of nitric oxide production, with IC values of 22.3 μM and 16.4 μM, respectively.

Article Abstract

Two previously undescribed ergosterols containing a highly conjugated ring system, psathrosterols A and B ( and ), have been isolated from the fungus . Their structures with absolute configurations were established by extensive spectroscopic methods, as well as single crystal X-ray diffraction. Compounds and showed inhibitory activity against NO production with IC values of 22.3 and 16.4 M, respectively.

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Source
http://dx.doi.org/10.1080/10286020.2023.2279539DOI Listing

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