AI Article Synopsis
- Nitric oxide (NO) is a short-lived gas important for signaling in blood vessels and various biological processes like immunity, inflammation, and aging.
- Fractional exhaled nitric oxide (FeNO) is a non-invasive method to measure airway inflammation, particularly in asthma, and is responsive to anti-inflammatory treatments.
- The review focuses on the use of FeNO as a biomarker for type 2 inflammation and its role in various allergic disorders, highlighting both past and current research findings.
Article Abstract
Nitric oxide (NO) is a short-lived gas molecule which has been studied for its role as a signaling molecule in the vasculature and later, in a broader view, as a cellular messenger in many other biological processes such as immunity and inflammation, cell survival, apoptosis, and aging. Fractional exhaled nitric oxide (FeNO) is a convenient, easy-to-obtain, and non-invasive method for assessing active, mainly Th2-driven, airway inflammation, which is sensitive to treatment with standard anti-inflammatory therapy. Consequently, FeNO serves as a valued tool to aid the diagnosis and monitoring of several asthma phenotypes. More recently, FeNO has been evaluated in several other respiratory and/or immunological conditions, including allergic rhinitis, chronic rhinosinusitis with/without nasal polyps, atopic dermatitis, eosinophilic esophagitis, and food allergy. In this review, we aim to provide an extensive overview of the current state of knowledge about FeNO as a biomarker in type 2 inflammation, outlining past and recent data on the application of its measurement in patients affected by a broad variety of atopic/allergic disorders.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10649630 | PMC |
| http://dx.doi.org/10.3390/cells12212518 | DOI Listing |
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