AI Article Synopsis
- Ferrofluidic robots show great potential for medical applications but face challenges when used inside the body due to biocompatibility and controllability issues.
- Researchers created a ferrofluid-based millirobot designed for in vivo tumor-targeted therapy, using corn oil to enhance biocompatibility and a 3D magnetic drive system for improved control in complex biological environments.
- The robot demonstrates effectiveness in killing tumor cells through photothermal conversion, with positive results in inhibiting tumor growth and increasing cancer cell death both in vitro and in vivo.
Article Abstract
Ferrofluidic robots with excellent deformability and controllability have been intensively studied recently. However, most of these studies are in vitro and the use of ferrofluids for in vivo medicinal applications remains a big challenge. The application of ferrofluidic robots to the body requires the solution of many key problems. In this study, biocompatibility, controllability, and tumor-killing efficacy are considered when creating a ferrofluid-based millirobot for in vivo tumor-targeted therapy. For biocompatibility problems, corn oil is used specifically for the ferrofluid robot. In addition, a control system is built that enables a 3D magnetic drive to be implemented in complex biological media. Using the photothermal conversion property of 1064 nm, the ferrofluid robot can kill tumor cells in vitro; inhibit tumor volume, destroy the tumor interstitium, increase tumor cell apoptosis, and inhibit tumor cell proliferation in vivo. This study provides a reference for ferrofluid-based millirobots to achieve targeted therapies in vivo.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/adhm.202302395 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!