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Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets. | LitMetric

AI Article Synopsis

  • - The study investigates InP/ZnS quantum dots (QDs) as a safer alternative to heavy metal-based QDs for in vivo platelet imaging, revealing their intrinsic fluorescence capabilities and potential applications.
  • - Various phase transfer agents are used to assess the biocompatibility of these quantum dots with platelet function, showing that QD-platelet interactions occur across all tested concentrations but lead to platelet aggregation as concentration increases.
  • - Advanced imaging techniques like fluorescent lifetime imaging microscopy (FLIM) demonstrate that QDs localize on platelets, suggesting energy transfer among QDs and paving the way for their use as fluorescent probes in platelet imaging.

Article Abstract

InP/ZnS quantum dots (QDs) have received a large focus in recent years as a safer alternative to heavy metal-based QDs. Given their intrinsic fluorescent imaging capabilities, these QDs can be potentially relevant for in vivo platelet imaging. The InP/ZnS QDs are synthesized and their biocompatibility investigated through the use of different phase transfer agents. Analysis of platelet function indicates that platelet-QD interaction can occur at all concentrations and for all QD permutations tested. However, as the QD concentration increases, platelet aggregation is induced by QDs alone independent of natural platelet agonists. This study helps to define a range of concentrations and coatings (thioglycolic acid and penicillamine) that are biocompatible with platelet function. With this information, the platelet-QD interaction can be identified using multiple methods. Fluorescent lifetime imaging microscopy (FLIM) and confocal studies have shown QDs localize on the surface of the platelet toward the center while showing evidence of energy transfer within the QD population. It is believed that these findings are an important stepping point for the development of fluorescent probes for platelet imaging.

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Source
http://dx.doi.org/10.1002/smll.202304881DOI Listing

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