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Frontal Plane Knee Kinematics and Kinetics During Gait in Children and Youth with Achondroplasia-Correspondence with Static X-Ray Images and Relevance to Symptoms.
Children (Basel)
January 2025
Specialist Centre for Paediatric Orthopaedics, Neuroorthopaedics and Deformity Reconstruction, Schön Clinic Vogtareuth, 83569 Vogtareuth, Germany.
: Frontal knee malalignments are hallmarks of Achondroplasia (ACH), along with disproportional short stature. Typically, X-rays are used to assess them, but 3D gait analysis (3DGA) may additionally be used to evaluate dynamic knee function. The research questions were as follows: (1) What is the relationship between X-rays and 3DGA in ACH? (2) Do children with ACH have abnormal frontal knee kinematics and kinetics? (3) Are there aspects of 3DGA that relate to knee symptoms? : A total of 62 knees of 31 children with ACH (age: 11.
View Article and Find Full Text PDFPancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines.
J Immunother Cancer
January 2025
Internal Medicine I, Ulm University Hospital, Ulm, Germany
Background: Pancreatic ductal adenocarcinoma (PDAC) is mostly refractory to immunotherapy due to immunosuppression in the tumor microenvironment and cancer cell-intrinsic T cell tolerance mechanisms. PDAC is described as a "cold" tumor type with poor infiltration by T cells and factors leading to intratumoral T cell suppression have thus received less attention. Here, we identify a cancer cell-intrinsic mechanism that contributes to a T cell-resistant phenotype and describes potential combinatorial therapy.
View Article and Find Full Text PDFThree-Dimensional Measurements of Sphenoid Sinus Size by Sex in a Korean Population: An Exploratory Study.
Diagnostics (Basel)
December 2024
Department of Bio Health Convergency Open Sharing System, Dan-Kook University, Cheonan 31116, Republic of Korea.
This study aims to investigate the three-dimensional morphological differences of the sphenoid sinus according to sex in the Korean adult population and conduct an exploratory study based on the findings. The sphenoid sinus, located deep within the skull, plays a crucial role in forensic identification due to its relative protection from external damage and its unique anatomical characteristics. Using cone-beam computed tomography (CBCT) data from 120 patients (60 males and 60 females) aged 20-29, the sphenoid sinus was visualized and measured in three dimensions using Mimics software (version 22.
View Article and Find Full Text PDFChickpea NCR13 disulfide cross-linking variants exhibit profound differences in antifungal activity and modes of action.
PLoS Pathog
December 2024
Donald Danforth Plant Science Center, St. Louis, Missouri, United States of America.
Article Synopsis
- Small antifungal peptides known as NCR peptides, particularly in legumes like chickpeas, show potential as biofungicides due to their ability to act against fungal pathogens through different mechanisms of action (MoA).
- The study focused on chickpea NCR13, which can form multiple disulfide bonds; two variants of this peptide, NCR13_PFV1 and NCR13_PFV2, were created, showing different structures and antifungal potency despite having the same amino acid sequence.
- NCR13_PFV1 was found to be more effective in killing fungal cells and inhibiting protein translation, resulting in better disease control in plants sprayed with it, emphasizing the importance of disulfide bond configuration in peptide
A novel non-contrast agent-enhanced 3D whole-heart magnetic resonance sequence for congenital heart disease patients: the REACT Study.
Pediatr Radiol
December 2024
Division of Pediatric Cardiology, Children's Health-University of Texas Southwestern Medical Center, 1935 Medical District Drive, Dallas, TX, 75235, USA.
Background: The three-dimensional balanced-steady-state-free-precession (3D bSSFP) whole-heart (WH) technique has long been used to depict cardiac morphology in congenital heart disease (CHD) but is prone to banding artifacts. The Relaxation Enhanced Angiography without Contrast and Triggering (REACT) sequence is an alternative method that is resistant to off-resonance effects.
Objective: To evaluate cardiac structures and great vessels in CHD patients using 3D WH REACT sequence and compare it to 3D WH bSSFP sequence.
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