Vehicle handling and stability performance and ride comfort is normally assessed through standard field test procedures, which are time consuming and expensive. However, the rapid development of digital technologies in the automotive industry have enabled to properly model and simulate the full-vehicle dynamics, thus drastically reducing design and manufacturing times and costs while enhancing the performance, safety, and longevity of vehicle systems. This paper focus on a computationally efficient multi-objective optimization framework for developing an optimal design of a vehicle steering system, which is carried out by coupling certain computer-aided design tools (CAD) and computer-aided engineering (CAE) software. The 3D CAD model of the steering system is made using SolidWorks, the Finite Element Analysis (FEA) is modelled using Ansys Workbench, while the multibody kinematic and dynamic is analysed using Adams/Car. They are embedded in a multidisciplinary optimization design framework (modeFrontier) with the aim of determining the optimal hardpoint locations of the suspension and steering systems. This is achieved by minimizing the Ackermann error and toe angle deviations, together with the volume, mass, and maximum stresses of the rack-and-pinion steering mechanism. This enhances the vehicle stability, safety, manoeuvrability, and passengers' comfort, extends the vehicle systems reliability and fatigue life, while reducing the tire wear. The method has been successfully applied to different driving scenarios and vehicle maneuvers to find the optimal Pareto front and analyse the performance and behaviour of the steering system. Results show that the design of the steering system can be significantly improved using this approach.
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http://dx.doi.org/10.1038/s41598-023-45349-z | DOI Listing |
Heliyon
January 2025
School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA.
Cellular forces regulate an untold spectrum of living processes, such as cell migration, gene expression, and ion conduction. However, a quantitative description of mechanical control remains elusive due to the lack of general, live-cell tools to measure discrete forces between biomolecules. Here we introduce a computational pipeline for force measurement that leverages well-defined, tunable release of a mechanically activated small molecule fluorophore.
View Article and Find Full Text PDFCardiovasc Diabetol
January 2025
Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Diabetic myocardial disorder (DbMD, evidenced by abnormal echocardiography or cardiac biomarkers) is a form of stage B heart failure (SBHF) at high risk for progression to overt HF. SBHF is defined by abnormal LV morphology and function and/or abnormal cardiac biomarker concentrations.
Objective: To compare the evolution of four DbMD groups based on biomarkers alone, systolic and diastolic dysfunction alone, or their combination.
Methods Mol Biol
January 2025
Department of Chemistry, Institute of Biomedical Sciences and Multiscale Research Institute of Complex Systems, Fudan University, Shanghai, China.
Steered Molecular Dynamics (SMD) simulation is a powerful computational simulation technique that enables the controlled manipulation of molecular systems by applying external forces. This method is frequently utilized to investigate the slow processes of biomolecular systems that occur within sub-second to second time scales, achieved through SMD simulations that only span nanoseconds. SMD simulation can be utilized to study the detailed mechanism of protein conformational changes, protein unfolding, and ligand dissociation, etc.
View Article and Find Full Text PDFNat Med
January 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Circulating tumor DNA (ctDNA) detection can predict clinical risk in early-stage tumors. However, clinical applications are constrained by the sensitivity of clinically validated ctDNA detection approaches. NeXT Personal is a whole-genome-based, tumor-informed platform that has been analytically validated for ultrasensitive ctDNA detection at 1-3 ppm of ctDNA with 99.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Emory University, Chemistry, 1515 Dickey Dr., 30322, Atlanta, UNITED STATES OF AMERICA.
Genetically encoded tension sensors (GETSs) allow for quantifying forces experienced by intracellular proteins involved in mechanotransduction. The vast majority of GETSs are comprised of a FRET pair flanking an elastic "spring-like" domain that gradually extends in response to force. Because of ensemble averaging, the FRET signal generated by such analog sensors conceals forces that deviate from the average, and hence it is unknown if a subset of proteins experience greater magnitudes of force.
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