AI Article Synopsis
- - Anthracnose, caused by the fungus Colletotrichum scovillei, is a major threat to chili crops globally, and a new fungicide called florylpicoxamid shows great promise in controlling this disease in China.
- - The study revealed that while florylpicoxamid has a moderate resistance risk from 141 fungal isolates, seven resistant mutants were identified with significant resistance factors but generally weaker growth traits than their original strains.
- - Genetic analysis found specific mutations (A37V and S207L) in the cytochrome b protein that relate to different resistance levels, providing insights for better application of this fungicide against chili anthracnose in the future.
Article Abstract
Anthracnose caused by Colletotrichum scovillei is one of the most destructive diseases of chili worldwide. Florylpicoxamid is a new quinone inside inhibitor (QiI) fungicide, which shows intensively inhibitory activity against C. scovillei. Currently, florylpicoxamid is in the registration process to control chili anthracnose in China. This study investigated the risk of resistance and resistance genetic mechanism of C. scovillei to florylpicoxamid. Baseline sensitivity of 141C. scovillei isolates to florylpicoxamid was established with an average EC value of 0.2328 ± 0.0876 μg/mL. A total of seven stable florylpicoxamid-resistant mutants were obtained with resistance factors ranging from 41 to 276. The mutants showed similar or weaker traits in mycelial growth, sporulation, conidial germination and pathogenicity than their parental isolates. Generally, the resistance risk of C. scovillei to florylpicoxamid would be moderate. In addition, there was no cross-resistance between florylpicoxamid and the commercially available fungicides tested. A37V and S207L mutations in the cytochrome b protein were detected in four high-resistance and three moderate-resistance mutants, respectively, of which, S207L is a new mutation. Molecular docking showed that the two mutations conferred different resistance levels to florylpicoxamid. These results provide a new perspective for QiI fungicide-resistance mechanism and may help in the reasonable use of florylpicoxamid against chili anthracnose in the future.
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| http://dx.doi.org/10.1016/j.pestbp.2023.105617 | DOI Listing |
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