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Objective: To describe the actual communication of patients with breast cancer on oral abemaciclib treatment and the motivating factors to continue treatment.
Methods: An online survey was conducted in July and August 2023 across Japan among patients aged ≥18 years who were undergoing or had prior experience with abemaciclib treatment and physicians who had prescribed abemaciclib during the past year.
Results: Responses from 80 patients and 78 physicians were obtained.
Ki-67 as a marker for differentiating borderline and benign phyllodes tumors of the breast: A meta-analysis and systematic review.
Ann Diagn Pathol
December 2024
Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX, USA.
Previously published studies raise the possibility of a link between breast phyllodes tumors (PT) grading and Ki-67 expression. In the current study, the authors conducted a literature review and meta-analysis to evaluate the association between the histological grades of PT and Ki-67 positivity, as well as the potential role of this immunomarker for the grading of PT. Observational studies grading PT and providing Ki-67 expression levels were retrieved from databases searches up to 11 August 2024, with 10 % or more of positive stromal cells being considered the cut-off point.
View Article and Find Full Text PDFConcurrent Amplification of Ferroptosis and Immune System Activation Via Nanomedicine-Mediated Radiosensitization for Triple-Negative Breast Cancer Therapy.
Adv Sci (Weinh)
December 2024
Department of Radiotherapy, The Second Hospital of Jilin University, Changchun, 130022, China.
Radiation therapy (RT) is one of the core therapies for current cancer management. However, the emergence of radioresistance has become a major cause of radiotherapy failure and disease progression. Therefore, overcoming radioresistance to achieve highly effective treatment for refractory tumors is significant yet challenging.
View Article and Find Full Text PDFResearch progress and application status of organoid in breast cancer subtypes.
Biomol Biomed
December 2024
Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.
Breast cancer (BC) is a prevalent malignant tumor that poses a significant health risk to women. The complexity of basic BC research and clinical treatment is influenced by multiple factors, including age, fertility, hormone metabolism, molecular subtypes, and tumor grading and staging. Traditional in vitro models often fall short of meeting modern research demands, whereas organoids-an emerging 3D primary culture technology-offer a unique platform that better replicates the tumor microenvironment (TME).
View Article and Find Full Text PDFDMOIT: denoised multi-omics integration approach based on transformer multi-head self-attention mechanism.
Front Genet
December 2024
Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea.
Multi-omics data integration has become increasingly crucial for a deeper understanding of the complexity of biological systems. However, effectively integrating and analyzing multi-omics data remains challenging due to their heterogeneity and high dimensionality. Existing methods often struggle with noise, redundant features, and the complex interactions between different omics layers, leading to suboptimal performance.
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