AI Article Synopsis
- The study analyzed opioid and non-opioid medication usage among pediatric cancer patients in the U.S. from 2005 to 2019.
- Over 71% of the 4,174 patients examined were prescribed opioids, with notable increases in the use of anticonvulsants, NSAIDs, and muscle relaxants over time.
- The research found a decrease in opioid prescriptions after 2012, suggesting a shift towards non-opioid treatments for managing pain in these young patients.
Article Abstract
Background: This study examined the trends and patterns of opioid and non-opioid pharmacotherapy use among a large national sample of privately insured pediatric patients with cancer in the United States.
Materials And Methods: We identified pediatric (aged < 21) patients diagnosed with central nervous system (CNS), lymphoma, gonadal, leukemia, or bone cancer from MarketScan data 2005-2019. We examined the proportion of patients who filled a prescription for the following 5 types of pharmacotherapy: opioid, anticonvulsant, non-steroidal anti-inflammatory drug (NSAID), antidepressant, and muscle relaxant during active cancer treatment. We assessed the trends and patterns in pharmacotherapy using multivariable logistic regressions.
Results: Among 4174 patients included, 2979 (71%) had an opioid prescription; 746 (18%), 384 (9%), 202 (5%), and 169 (4%) had anticonvulsant, NSAID, antidepressant and muscle relaxant prescriptions, respectively. Multivariable logistic regression showed a nonlinear trend in the use of opioids among pediatric patients with cancer over time such that use slightly increased until 2012 (OR of 1.40 [95% CI, 1.12-1.73] for 2012 vs. 2006) but then decreased thereafter (OR of 0.51 [0.37-0.68] for 2018 vs. 2012). The use of anticonvulsants, NSAIDs, and muscle relaxants increased significantly linearly over time (all P < .005).
Conclusion: There has been a downward trend in the use of opioids in recent years among pediatric patients with cancer and an upward trend in the use of non-opioid pharmacotherapy for pain management potentially as an alternative to opioids.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836308 | PMC |
| http://dx.doi.org/10.1093/oncolo/oyad292 | DOI Listing |
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