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Modelling Hollow Microneedle-Mediated Drug Delivery in Skin Considering Drug Binding.
Pharmaceutics
January 2025
Department of Mathematics, Visva-Bharati University, Santiniketan 731235, WB, India.
Microneedle(MN)-based drug delivery is one of the potential approaches to overcome the limitations of oral and hypodermic needle delivery. An in silico model has been developed for hollow microneedle (HMN)-based drug delivery in the skin and its subsequent absorption in the blood and tissue compartments in the presence of interstitial flow. The drug's reversible specific saturable binding to its receptors and the kinetics of reversible absorption across the blood and tissue compartments have been taken into account.
View Article and Find Full Text PDFArtificial Intelligence-Based Detection and Numbering of Dental Implants on Panoramic Radiographs.
Clin Implant Dent Relat Res
February 2025
SEMRUK Technology Inc., Cumhuriyet Teknokent, Sivas, Turkiye.
Objectives: This study aimed to develop an artificial intelligence (AI)-based deep learning model for the detection and numbering of dental implants in panoramic radiographs. The novelty of this model lies in its ability to both detect and number implants, offering improvements in clinical decision support for dental implantology.
Materials And Methods: A retrospective dataset of 32 585 panoramic radiographs, collected from patients at Sivas Cumhuriyet University between 2014 and 2024, was utilized.
Evaluation of physicochemical property changes in 3D-printed biodegradable medical devices under simulated oral physiological conditions.
Biomed Mater
January 2025
Department of Biosystems Engineering, Seoul National University, Seoul 08826, Republic of Korea.
Biodegradable medical devices undergo degradation following implantation, potentially leading to clinical failure. Consequently, it is necessary to assess the change in their properties post-implantation. However, a standardized method for the precise evaluation of the changes in their physicochemical properties is currently lacking.
View Article and Find Full Text PDFSocial isolation increases impulsive choice with minor changes on metabolic function in middle-aged rats.
Physiol Rep
January 2025
Department of Psychology, University of Illinois Urbana-Champaign, Champaign, Illinois, USA.
The effects of social isolation (SI) during middle age remain unclear, so we tested the hypothesis that SI would lead to an increase in impulsive choice (IC), anxiety-like behavior, and metabolic dysfunction in middle-aged rats. Male and female rats were housed individually or in groups of four with same-sex housing mates at 11 months of age. Two months later, IC behavior was assessed using a delay-discounting task and anxiety-like behavior through a novelty-suppressed feeding (NSF) task.
View Article and Find Full Text PDFModeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis.
Hum Cell
January 2025
Integrated Head and Neck Oncology Program (DSRG-5), Mazumdar Shaw Medical Foundation, Narayana Health, Bangalore, India.
Article Synopsis
- The study investigates lymph node stromal cell cultures (LNSCs) from oral squamous cell carcinoma (OSCC) patients to understand tumor interactions for better treatment options.
- Primary cultures were developed from both metastatic and non-metastatic patient nodes, confirming their purity and revealing a variety of cell types.
- Transcriptomic and cytokine profiling showed different molecular alterations based on node status, with key insights into immune response and potential pathways for metastasis, highlighting the relevance of these models for future cancer research.
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