AI Article Synopsis
- - The study investigates the link between serum cholinesterase (SChE) levels and the prevalence of atrial fibrillation (AF) in hypertensive patients, as previous research suggests a connection between non-alcoholic fatty liver disease (NAFLD) and AF.
- - An analysis of data from 748 hypertensive patients revealed that higher SChE levels are significantly associated with a lower occurrence of AF, regardless of the presence of fatty liver disease.
- - These findings indicate a negative correlation between SChE levels and AF in hypertensive individuals, suggesting that SChE might play a role in AF risk assessment.
Article Abstract
Background: Atrial fibrillation (AF) is a very common arrhythmia with significant incidence rate and mortality. Several studies have shown a notable correlation between non-alcoholic fatty liver disease (NAFLD) and AF. It has been observed that serum cholinesterase (SChE) levels are elevated in individuals with fatty liver. However, the relationship between the SChE index and AF is still unclear. Therefore, the purpose of this study is to explore the association between the SChE index and the prevalence of AF in patients with hypertension.
Method: We collected cross-sectional data from January 2018 to April 2021 based on a retrospective study of cardiovascular disease. A total of 748 patients with hypertension were included, of whom 165 had AF. We used logistic regression models to test the relationship between SChE and the prevalence of AF in hypertensive patients.
Result: In hypertensive patients, the SChE index was significantly associated with AF (OR = 0.723, P < 0.001). After adjusting for potential confounding factors, this correlation was still significant (OR = 0.778, P < 0.001). The stability of the model was verified by adjusting the variable type of SChE. The data were further stratified according to whether the patient had fatty liver. In the stratified data, the correlation between SChE and atrial fibrillation was still significant (P < 0.05).
Conclusion: Our study showed that SChE was significantly negatively correlated with the occurrence of AF in patients with hypertension. And this correlation was not affected by whether the patient had fatty liver.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631021 | PMC |
| http://dx.doi.org/10.1186/s40001-023-01474-z | DOI Listing |
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