Background: The etiology of tendinopathy remains controversial and it is unknown whether degenerative structural changes in tendinopathies are reversible.
Hypothesis: There will be no structural change on magnetic resonance imaging (MRI) taken > 2-years after treatment for gluteal tendinopathy.
Study Design: Extension of a single site, double-blind, prospective randomized-controlled trial to analyze the additional outcome measure; MRI changes.
Methods: University of Melbourne ethics approval number: 1852900, trial registration: ACTRN12613000677707. Participants with gluteal tendinopathy who had previously received a leukocyte-rich platelet-rich plasma injection (LR-PRP) or a corticosteroid injection (CSI) had a post treatment MRI between at least 2-years and up to 7 years following trial completion. A blinded, senior musculoskeletal radiologist graded all de-identified MRI scans using the Melbourne Hip Score (MHIP). The primary outcome measure was the change in overall pre- and post-treatment score.
Results: Participants (n = 20) underwent MRI at mean time of 4.15 (SD 1.11; range 2-7) years after their initial treatment. There was no change in the overall mean MHIP score for the CSI group (Pre 4.3 (SD 2.3) Post 4.3 (SD 1.1), p = 1.00). Although there was an improvement in the LR-PRP group mean MHIP score (Pre 5.3 (SD 3.0) Post 4.77 (SD 2.5), p = 0.56) it was not statistically significant. However, in the LR-PRP intervention group, five out of nine of participants' MHIP score improved, with four of these improving by 2-4 points.
Conclusion: The hypothesis that there would be no improvement in MHIP scores following treatment of gluteal tendinopathy was supported. Findings of improvement in the LR-PRP group at 4 years would support further studies powered to look for structural improvement. These findings suggest that structural change following treatment for tendinopathy may be possible supporting the inclusion of MRI as a core outcome for future studies.
Clinical Relevance: The study suggests that degenerative structural changes in tendons may be reversible.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634075 | PMC |
| http://dx.doi.org/10.1186/s12880-023-01150-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Incongruent Expectations: A Qualitative Study of the Gendered Experiences of Canadian Young People.
Qual Health Res
January 2025
Department of Criminology, University of Ottawa, Ottawa, ON, Canada.
While the early mental health of girls and boys is similar, as children age, girls tend to report worse mental health than boys. Explanations for these gendered disparities remain elusive. This study seeks to understand the social context in which mental health experiences are shaped.
View Article and Find Full Text PDFSteroids and steroid-like compounds alter the ion permeability of phospholipid bilayers distinct interactions with lipids and interfacial water.
Phys Chem Chem Phys
January 2025
School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia QLD 4072, Australia.
Steroids are organic compounds found in all forms of biological life. Besides their structural roles in cell membranes, steroids act as signalling molecules in various physiological processes and are used to treat inflammatory conditions. It has been hypothesised that in addition to their well-characterised genomic and non-genomic pathways, steroids exert their biological or pharmacological activities an indirect, nonreceptor-mediated membrane mechanism caused by steroid-induced changes to the physicochemical properties of cell membranes.
View Article and Find Full Text PDFPaediatric-to-adult transition in type 1 diabetes: A two-centre experience of a structured program, 2014 to 2022.
Diabetes Obes Metab
January 2025
Endocrinologie, Diabétologie Et Gynécologie Pédiatrique, Hopital Necker-Enfants Malades, Université Paris Cité, AP-HP centre, Paris, France.
Background: Transition from paediatric to adult healthcare is a turning point for patients with Type 1 diabetes (T1D). A gradual coordinated process connecting paediatric and adult healthcare providers may improve adherence to adult follow-up.
Aims: To describe a transition process developed jointly by paediatric and adult diabetology units and compare patients progressing or not to follow-up in adult care setting.
Adsorption Structure and Selectivity of Phenols in Water-Immersed Organomontmorillonite Investigated by Molecular Simulation.
Langmuir
January 2025
Department of Environmental Chemistry and Chemical Engineering, School of Advanced Engineering, Kogakuin University, 2665-1 Nakano, Tokyo, Hachioji 192-0015, Japan.
The two-dimensional interlayer space of layered materials has been highlighted due to their adsorption property, whose nanostructure in the water-immersed state is scarcely understood by experiment. Recent developments in molecular simulation have enabled researchers to investigate the interlayer structure, but water content is necessary for accurate modeling. In the present study, we proposed a theoretical method to estimate the saturated water content and adsorption selectivity of trichlorophenol and phenol in montmorillonite modified with hexadecyltrimethylammonium ions.
View Article and Find Full Text PDF"There's a Little Bit of Tension There:" Perspectives of Mothers and Early Childhood Educators on Breastfeeding in Child Care Centers.
Public Health Nutr
January 2025
Department of Pediatrics, Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States.
Objective: To explore mothers' and early childhood (EC) educators' experiences of breastfeeding/breast milk provision and breastfeeding support in child care centers (CCCs) in the United States (U.S.).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!